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Abilify vs. Zyprexa Prescription Treatment for Schizophrenia: Difference and Side Effects

Abilify vs. Zyprexa

Are Abilify and Zyprexa the Same Thing?

Abilify (aripiprazole) and Zyprexa (olanzapine) are antipsychotic medications used to treat schizophrenia and mania.

Abilify is also used to treat depression, bipolar disorders, autistic disorder, and some irritable behavior disorders.

What Are Possible Side Effects of Abilify?

Common side effects of Abilify include:

  • dizziness
  • lightheadedness
  • drowsiness
  • weakness
  • lightheadedness
  • nausea
  • vomiting
  • stomach upset
  • tiredness
  • excess saliva or drooling
  • choking or trouble swallowing
  • blurred vision
  • headache
  • anxiety
  • weight gain
  • drowsiness
  • sleep problems (insomnia)
  • constipation

What Are Possible Side Effects of Zyprexa?

Common side effects of Zyprexa include:

  • stomach upset,
  • nausea,
  • vomiting,
  • flushing (warmth, redness, or tingly feeling),
  • constipation,
  • headache,
  • confusion,
  • memory problems,
  • loss of balance or coordination,
  • blurred vision,
  • double vision,
  • eye redness,
  • lightheadedness,
  • dizziness,
  • spinning sensation,
  • drowsiness,
  • sleep problems (insomnia),
  • stuffy nose,
  • itching, or
  • rash, especially during the first few days as your body adjusts to this medication.

Tell your doctor if you experience serious side effects of Zyprexa including:

  • fever,
  • chills,
  • flu symptoms,
  • slow heart rate,
  • feeling like you might pass out,
  • seizures (convulsions), or
  • jaundice (yellowing of your skin or eyes).

What Is Abilify?

Abilify (aripiprazole) is a psychotropic drug (antipsychotic) that alters brain chemical activity used to treat schizophrenia, mania, depression, bipolar disorders, autistic disorder, and some irritable behavior disorders. Generic Abilify is not available in the U.S., but is available in other countries under the name aripiprazole.

What is Zyprexa?

Zyprexa (olanzapine) is an atypical antipsychotic medication used to treat schizophrenia and manic episodes of bipolar disorder.

What Drugs Interact With Abilify?

Abilify (aripiprazole) is a psychotropic drug (antipsychotic) that alters brain chemical activity used to treat schizophrenia, mania, depression, bipolar disorders, autistic disorder, and some irritable behavior disorders. Generic Abilify is not available in the U.S., but is available in other countries under the name aripiprazole.

Abilify may also interact with rifabutin, rifampin, or quinidine.

Acute withdrawal symptoms, such as insomnia, nausea, and vomiting may occur if you suddenly stop taking Zyprexa.

What Drugs Interact With Zyprexa?

Zyprexa may interact with other medicines that can make you sleepy or slow your breathing (such as cold or allergy medicines, narcotic pain medicines, sleeping pills, muscle relaxers, and medicines for depression, seizure, anxiety), and heart or blood pressure medications. Zyprexa may also interact with carbamazepine, diazepam, fluoxetine, olanzapine, fluvoxamine, omeprazole, rifampin, or medications to treat Parkinson's disease.

How Should Abilify Be Taken?

Abilify is available in tablet, orally disintegrating tablets, oral solution and injectable formulations. Dosage is variable and depends on multiple factors such as the ongoing mental problem, patient age, and other factors to be determined by the prescribing doctor. Abilify has been used in the pediatric population but such use should be discussed with a pediatric specialist. Abilify may interact with other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), medications to treat high blood pressure or a heart condition, carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, ketoconazole, itraconazole, quinidine, fluoxetine, fluvoxamine, or paroxetine. Tell your doctor all medications and supplements you use. Benefits should outweigh risks in pregnant women. Women who are breastfeeding should not take Abilify.

How Should Zyprexa Be Taken?

The recommended starting dose of Zyprexa is six grams a day for the first 48 to 72 hours of treatment. Thereafter, the dosage can usually be reduced to approximately 4 grams a day. Zyprexa may interact with pyridostigmine, donepezil, galantamine, rivastigmine, or tacrine. Tell your doctor all prescription and over-the-counter medications and supplements you use. Zyprexa should be used during pregnancy only when prescribed. It is not known if this drug passes into breast milk. Consult your doctor before breastfeeding.

Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

Otsuka. Abilify Medication Guide.
https://www.otsuka-us.com/media/static/Abilify-MedGuide.pdf?_ga=2.165275711.1805087339.1508442435-524091158.1508442435
Lilly. Zyprexa Prescribing Information.
https://pi.lilly.com/us/zyprexa-pi.pdf