Aceclidine Ophthalmic

Aceclidine Ophthalmic is a prescription medication indicated for the treatment of presbyopia in adults.

• Aceclidine Ophthalmic is available under the following different brand names: Vizz

Common side effects of Aceclidine Ophthalmic include:

• instillation site irritation
• dim vision 
• headache

Serious side effects of Aceclidine Ophthalmic include:

• risk of retinal tear/detachment
• iritis
• blurred vision
• hypersensitivity
• potential for eye injury or contamination

Rare side effects of Aceclidine Ophthalmic include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Ophthalmic solution

• 1.44% single-dose vial

Presbyopia

Adult dosage

• Instill 1 drop in each eye, wait 2 minutes, and instill a second drop in each eye daily

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

Tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Visit the RxList Drug Interaction Checker for any drug interactions. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• None

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Aceclidine Ophthalmic?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Aceclidine Ophthalmic?”

Cautions

• Blurred vision
• Miotics may cause accommodative spasm
• Do not drive or operate machinery if vision is not clear (e.g., blurred vision)
• Patients may experience temporary dim or dark vision
• Exercise caution in night driving and other hazardous activities in poor illumination
• Retinal tear/detachment
  • Rare cases of retinal tears and detachment have been reported with miotics when used in susceptible individuals and those with pre-existing retinal diseases
  • Examine the retina in all patients before prescribing
  • Inform patients to seek immediate care with the sudden onset of flashing lights, floaters, or vision loss
• Iritis
  • Sequelae of ocular inflammation (ie, adhesions [synechiae]) between iris and lens may be exacerbated with the use of miotics in patients with a known history of iritis
• Hypersensitivity
  • Not recommended for use in patients with a known hypersensitivity to aceclidine or any other ingredient
• Using contact lenses
  • Remove contact lenses before instilling Aceclidine Ophthalmic solution
  • May reinsert contacts 10 minutes after instillation
  • Potential for eye injury or contamination
  • Avoid touching the single-dose vial to the eye or to any other surface to prevent eye injury or contamination

Pregnancy and Lactation

• There are no adequate and well-controlled studies of administration during pregnancy to inform a drug-associated risk
• Lactation
  • There is no information regarding the presence of aceclidine or its metabolite in human or animal milk, its effects on breastfed infants, or milk production
  • Systemic levels of aceclidine and its metabolites following topical ocular administration are low