Acetohydroxamic Acid

Acetohydroxamic acid is used for chronic urinary tract infection (UTI) caused by urea-splitting organisms.

Acetohydroxamic acid is available under the following different brand names: Lithostat.

Dosages of Acetohydroxamic Acid:

Dosage Forms and Strengths

Tablet

• 250mg

Dosage Considerations – Should be Given as Follows:

Chronic Urinary Tract Infection

• Indicated for chronic UTIs caused by urea-splitting organisms
• Adult, Initial: 12 mg/kg/day orally divided every 6-8 hours on an empty stomach
• Adult, Maintenance: 250 mg orally every 6-8 hours; not to exceed 1.5 g/day
• Pediatric, Initial: 10 mg/kg/day orally divided every 6-8 hours on empty stomach; titrate to patient response

Renal Impairment

• SCr 1.8-2.5 mg/dL [159-221 micromoles/L]: Dose every 12 hours; not to exceed 1 g/day
• SCr greater than 2.5 mg/dL [greater than 221 micromoles/L]: Not recommended

Side effects of Acetohydroxamic Acid include:

• Mild headache; first 48 hours
• Loss of appetite
• Feeling unwell (malaise)
• Nausea
• Vomiting
• Anxiety
• Confusion
• Depression
• Involuntary quivering
• Hemolytic anemia

Less common side effects of acetohydroxamic acid include:

• Hair loss
• Blood clot
• Macular rash
• Phlebitis

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

• Acetohydroxamic acid has no listed severe interactions with other drugs.
• Acetohydroxamic acid has no listed serious interactions with other drugs.
• Moderate interactions of acetohydroxamic acid include:
  • sodium picosulfate/magnesium oxide/anhydrous citric acid
• Mild interactions of acetohydroxamic acid include:
  • ethanol
  • ferric maltol
  • ferrous fumarate
  • ferrous gluconate
  • ferrous sulfate
  • rose hips

Warnings

• This medication contains acetohydroxamic acid. Do not take Lithostat if you are allergic to acetohydroxamic acid or any ingredients contained in this drug.
• Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• Hypersensitivity
• Patients amenable to definitive surgery and antimicrobial agents, infection by non-urease producing organisms, urinary infections controlled by culture-specific antimicrobials, severe renal impairment (CrCl less than 20 mL/minutes and/or serum creatinine greater than 2.5 mg/dL [221 umol/L]), inadequate contraception (females), pregnancy

Effects of Drug Abuse

• No information is available

Short-Term Effects

• See "What Are Side Effects Associated with Using Acetohydroxamic Acid?"

Long-Term Effects

• See "What Are Side Effects Associated with Using Acetohydroxamic Acid?"

Cautions

• Always use with appropriate antimicrobial treatment
• Potential teratogen

Pregnancy and Lactation

• Do not use acetohydroxamic acid in pregnancy. The risks involved outweigh the potential benefits. Safer alternatives exist.
• It is unknown if acetohydroxamic acid is excreted in breast milk unknown. Acetohydroxamic acid is not recommended for use while breastfeeding.