Ambenonium

Ambenonium is used to treat myasthenia gravis. Ambenonium was discontinued by the manufacturer on 6/25/2012.

Ambenonium is available under the following different brand names: Mytelase.

Dosages of Ambenonium:

Tablet

• 10 mg

Dosage Considerations – Should be Given as Follows:

Myasthenia Gravis

• Discontinued by the manufacturer (6/25/2012)
• Adult Initial: 5 mg orally every 6-8 hours
• Adult Maintenance: 15-100 mg/day, usual 40 mg/day
• Up to 50-75 mg orally every 6-8 hours use
• Pediatric Initial: 0.3 mg/kg/day divided every 6-8 hours orally
• Pediatric Maintenance: 1.5 mg/kg/day divided every 6-8 hours orally

Common side effects of ambenonium include:

• Urinary urgency
• Salivation
• Vomiting
• Nausea
• Diarrhea
• Tearing
• Constricted pupils
• Increased bronchial secretions
• Increased sweating
• Muscle cramps
• Muscle twitching

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Ambenonium has no listed severe interactions with other drugs.
• Ambenonium has no listed serious interactions with other drugs.
• Ambenonium has no listed moderate interactions with other drugs.
• Ambenonium has no listed mild interactions with other drugs.

Warnings

• This medication contains ambenonium. Do not take Mytelase if you are allergic to ambenonium or any ingredients contained in this drug.

Contraindications

• Hypersensitivity
• Mechanical obstruction of intestinal or urinary tracts
• Concurrent administration with belladona derivatives or ganglionic blocking agents such as mecamylamine

Effects of Drug Abuse

• No information is available.

Short-Term Effects

• See "What Are Side Effects Associated with Using Ambenonium?"

Long-Term Effects

• See "What Are Side Effects Associated with Using Ambenonium?"

Cautions

• May develop anticholinergic insensitivity (withhold or reduce dosages until the patient becomes sensitive again
• Use caution in patients with intestinal obstruction, asthma, urinary tract obstruction, or Parkinson's disease
• The narrow therapeutic index may increase the risk of overdosage

Pregnancy and Lactation

• Use ambenonium with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal l nor human studies were done.
• It is unknown if ambenonium is excreted into breast milk. The use of ambenonium is not recommended while breastfeeding.