Aminohippurate Sodium

Aminohippurate Sodium is a diagnostic agent used for the estimation and measurement of renal function (effective renal plasma flow and tubular secretion).

• Aminohippurate Sodium is available under the following different brand names: Para-amino Hippurate (PAH)

Common side effects of Aminohippurate Sodium  include:

1. a sensation of warmth, and
2. desire to defecate or urinate during or shortly after infusion

Serious side effects of Aminohippurate Sodium include:

• hives,
• difficulty breathing,
• swelling of the face, lips, tongue, or throat,
• swelling,
• itching,
• rash,
• night sweats,
• hot flashes,
• flushing,
• tingling,
• nausea,
• vomiting, and
• muscle cramps

Rare side effects of Aminohippurate Sodium include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out. 

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Injectable solution

• 20%

Renal Function Diagnostic

Adult dosage

• The goal is to maintain a plasma concentration of 2 mg/dL
• Load 6-10 mg/kg, infuse at 10-24 mg/min

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Aminohippurate Sodium has severe interactions with no other drugs.
• Aminohippurate Sodium has serious interactions with no other drugs
• Aminohippurate Sodium has moderate interactions with the following drugs:
  • methotrexate
  • mycophenolate
  • probenecid
• Aminohippurate Sodium has minor interactions with at least 63 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Aminohippurate Sodium?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Aminohippurate Sodium?”

Cautions

• Low cardiac reserve
• Latex-sensitive individuals: Vial stopper contains dry natural latex
• Administer IV solutions with caution to patients with low cardiac reserve (rapid increase in plasma volume may precipitate congestive heart failure

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during pregnancy.
• Lactation
  • Excretion in milk unknown; use with caution