Anhydrous Morphine

Anhydrous Morphine is a prescription medication used for treating diarrhea.

• Anhydrous Morphine is available under various brand names: Paregoric.

Common side effects of Anhydrous Morphine include:

• lightheadedness,
• dizziness,
• drowsiness,
• tiredness,
• restlessness,
• nausea,
• vomiting,
• upset stomach,
• loss of appetite,
• constipation,
• increased sweating, or
• flushing (warmth, redness, or tingly feeling under your skin).

Serious side effects of Anhydrous Morphine include:

• severe constipation, bloating, stomach cramps;
• urinating less than usual or not at all;
• fast, pounding, or uneven heartbeats;
• feeling like you might pass out;
• weak or shallow breathing; or
• seizures (convulsions).

Rare side effects of Anhydrous Morphine include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Oral liquid, Schedule III

• 473 mL/bottle
• Each 5 mL contains 2 mg of anhydrous Morphine

Diarrhea

Adult dosage

• 5 -10 mL orally every day or every 6 hours or as directed by a physician

Pediatric dosage

• 0.25-0.5 mL/kg orally every day or every 6 hours or as directed by a physician

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Anhydrous Morphine has severe interactions with no other drugs.
• Anhydrous Morphine  has serious interactions with no other drugs.
• Anhydrous Morphine has moderate interactions with the following drugs:
  • daridorexant
  • difelikefalin
  • ganaxolone
• Anhydrous Morphine has minor interactions with no other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to Morphine

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Anhydrous Morphine?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Anhydrous Morphine?”

Cautions

• Respiratory depressant effects of narcotics and their ability to elevate cerebrospinal-fluid pressure may be potentiated in the presence of head injury, other intracranial lesions, or a preexisting increase in intracranial pressure; additional effects of narcotics may obscure the clinical course in patients with head injuries
• Administration of narcotics like Morphine may obscure the diagnosis or clinical course in patients with acute abdominal conditions
• Use with caution in geriatric patients, debilitated, or patients with severe hepatic or renal impairment
• Exercise extreme caution in patients with disorders characterized by hypoxia
• May cause severe hypotension in the postoperative patients or any individual who has difficulty maintaining blood pressure due to depletion of blood volume or administration of such drugs as the phenothiazines or certain anesthetic
• Owing to possible vagolytic action which significantly increases the ventricular response rate, use with caution in patients with atrial flutter and other supraventricular tachycardias
• Preexisting convulsions may be aggravated in patients with convulsive disorders; especially in doses above recommended levels because of tolerance development
• May impair the mental and/or physical abilities required for performing potentially hazardous tasks, such as driving a car or operating machinery
• Drug interaction overview
  • Coadministration with other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative/hypnotics, or other CNS depressants (eg, alcohol) has additive depressant effects, and counsel patient
  • Consider reducing the dosage of one or both agents when coadministered with such agents

Pregnancy & Lactation

• It is not known whether fetal harm may occur when administered to pregnant female or can affect reproduction capacity
• Treat pregnant females only if clearly needed
• Lactation
  • Morphine appears in the milk of nursing mothers
  • Exercise caution when is administered to nursing females