Anti-Inhibitor Coagulant Complex

Anti-Inhibitor Coagulant Complex is a prescription medication used in hemophilia A and B patients with inhibitors for prevention and control of bleeding episodes, perioperative management, and for routine prophylaxis to prevent or reduce the frequency of bleeding episodes. 

• Anti-Inhibitor Coagulant Complex is available under the following different brand names: Feiba NF, Feiba VH Immuno.

Common side effects of Anti-Inhibitor Coagulant Complex include:

• fever
• chills
• pain around the IV needle
• numbness or tingling (especially in the face)
• changes in blood pressure or heart rate
• headache
• flushing

Serious side effects of Anti-Inhibitor Coagulant Complex include:

• chest pain
• cough
• rash and joint pain
• sudden weakness
• trouble breathing
• fast heartbeat
• hives, or
• hoarseness

Rare side effects of Anti-Inhibitor Coagulant Complex include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Powder for reconstitution

• 500 units
• 1000 units
• 2500 units

Hemophilia A & B

Adult and pediatric dosage

• Prevention and control of bleeding
  • Joint hemorrhage: 50 units/kg IV every 12 hours; may increase to 100 units/kg every 12 hours; continue until signs of clinical improvement occur; not to exceed 200 mg/kg/day
  • Mucous membrane bleed: 50 units/kg IV every 6 hours, may increase to 100 units/kg every 6 hours for 2 doses maximum; not to exceed 200 units/kg/day
  • Soft tissue hemorrhage: 100 units/kg IV q12hr; not to exceed 200 units/kg/day
  • Severe hemorrhage (eg, CNS bleed): 100 units/kg IV every 6-12 hours; not to exceed 200 units/kg/day unless the severity of hemorrhage justifies higher doses
• Perioperative management
  • Preoperative: 50-100 units/kg IV once immediately prior to surgery
  • Postoperative: 50-100 units/kg IV every 6-12 hours until resolution of bleeding and healing is achieved
• Routine prophylaxis
  • 85 units/kg IV every other day

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Anti-Inhibitor Coagulant Complex has minor interactions with the following drug:
  • prothrombin complex concentrate, human
• Anti-Inhibitor Coagulant Complex has minor interactions with the following drugs:
  • tranexamic acid injection
  • tranexamic acid oral
• Anti-Inhibitor Coagulant Complex has minor interactions with no other drugs.
• Anti-Inhibitor Coagulant Complex has minor interactions with no other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• Treatment of bleeding occurrences resulting from deficiencies in coagulation factors VIII or IX
• DIC
• Normal coagulation mechanisms present

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Anti-Inhibitor Coagulant Complex?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Anti-Inhibitor Coagulant Complex?”

Cautions

• Neonates (risk of thrombosis and/or hepatitis)
• Risk of transmissible infectious disease from human plasma (rare)
• Possibility of transient hypofibrinogenemia in children
• Administer to pregnant patients only if the benefits outweigh the risks
• Caution in patients with hepatic impairment
• Small amounts of factor VIII in the formulation may cause an anamnestic response
• Avoid or delay use in patients receiving treatment with antifibrolytic agents
• Only use to control bleeding in patients with coagulation deficiencies
• Discontinue in case of severe hypersensitivity reactions

Pregnancy and Lactation

• Use with caution if benefits outweigh risks during pregnancy
• Lactation
  • Not studied