Brilliant Blue G Ophthalmic Solution

Brilliant blue G ophthalmic solution is a disclosing agent indicated to selectively stain the internal limiting membrane.

• Brilliant Blue G Ophthalmic is available under the following different brand names: TissueBlue

Common side effects of Brilliant Blue G Ophthalmic include:

• none

Serious side effects of Brilliant Blue G Ophthalmic include:

• retinal break, tear, hemorrhage, and detachment 
• cataracts

Rare side effects of Brilliant Blue G Ophthalmic include:

• none 

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Injection, intravitreal solution

• 0.025% solution in prefilled 2.25-mL syringe (filled to volume of 0.5 mL)

Internal Limiting Membrane Staining

Adult dosage

• Inject into balanced salt solution (BSS)-filled the vitreous cavity using a blunt cannula attached to the prefilled syringe, without allowing the cannula to contact the retina or allowing the stain to get under the retina
• Sufficient staining is expected within a few seconds
• Remove all excess dye from the vitreous cavity following staining

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, healthcare provider, or pharmacist first.

• Brilliant Blue G Ophthalmic has no noted severe interactions with any other drugs
• Brilliant Blue G Ophthalmic has no noted serious interactions with any other drugs
• Brilliant Blue G Ophthalmic has no noted moderate interactions with any other drugs
• Brilliant Blue G Ophthalmic has no noted minor interactions with any other drugs

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• None

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Brilliant Blue G Ophthalmic?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Brilliant Blue G Ophthalmic?”

Cautions

• Excessive staining; remove excess solution from the eye immediately after staining
• Ensure the syringe plunger moves smoothly before injecting the solution; do not use it if the plunger does not move smoothly to prime the cannula

Pregnancy and Lactation

• Data are not available on the use in pregnant women to inform a drug-associated risk
• Systemic absorption in humans is expected to be negligible following intravitreal injection and subsequent removal of the drug after surgical procedures
• Owing to negligible systemic exposure, it is not expected that maternal use will result in fetal exposure to the drug
• Adequate animal reproduction studies were not conducted
• Lactation
  • Data are not available; however, breastfeeding is not expected to result in drug exposure to the child