Brimonidine and Timolol Ophthalmic

Brimonidine and Timolol Ophthalmic is a combination prescription medication used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). 

• Brimonidine and Timolol Ophthalmic are available under various brand names: Combigan 

Common side effects of Brimonidine and Timolol Ophthalmic include:

• drowsiness, tired feeling.
• mild itching, redness, or irritation of the eyes; or
• mild stinging or burning when using the eye drops.

Serious side effects of Brimonidine and Timolol Ophthalmic include:

• hives; 
• difficult breathing; 
• swelling of the face, lips, tongue, or throat.
• slow or uneven heart rate.
• pounding heartbeats or fluttering in the chest.
• shallow breathing, light-headedness;
• severe swelling, redness, or discomfort in or around the eye.
• eye pain or increased watering; or
• numbness or tingly feeling in your hands or feet.

Rare side effects of Brimonidine and Timolol Ophthalmic include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
• Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric 

Ophthalmic solution

• (5 mg/2 mg)/ mL (0.5%/0.2%)

Elevated intraocular pressure:

Adult dosage

• Ophthalmic: Instill 1 drop into the affected eye(s) twice daily.

Pediatric dosage

• Children Above 2 years: Ophthalmic: Instill 1 drop into the affected eye(s) twice daily

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Brimonidine and Timolol Ophthalmic have severe interactions with the following drugs:
  • isocarboxazid
  • linezolid
  • phenelzine
  • procarbazine
  • rasagiline
  • selegiline
  • selegiline transdermal
  • tranylcypromine
• Brimonidine and Timolol Ophthalmic have serious interactions with at least 35 other drugs
• Brimonidine and Timolol Ophthalmic have moderate interactions with at least 220 other drugs
• Brimonidine and Timolol Ophthalmic have minor interactions with at least 195 other drugs

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to Brimonidine and Timolol Ophthalmic
• a history of asthma or chronic obstructive pulmonary disease (COPD); or
• a serious heart condition such as "AV block," severe heart failure, or slow heartbeats that have caused you to faint. 

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Brimonidine and Timolol Ophthalmic?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Brimonidine and Timolol Ophthalmic?”

Cautions

• You should not use brimonidine and timolol Ophthalmic if you have a history of asthma or chronic obstructive pulmonary disease (COPD), or a serious heart condition such as "AV block," severe heart failure, or slow heartbeats that have caused you to faint.
• Brimonidine and timolol Ophthalmic should not be given to a child younger than 2 years old.
• This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
• Do not use other eye medications unless your doctor tells you to.

Pregnancy and Lactation

• It is not known whether brimonidine and timolol Ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
• Lactation
  • Timolol Ophthalmic can pass into breast milk and may harm a nursing baby. You should not breastfeed while using this medicine.