Calcified granuloma: A node-like type of tissue inflammation that has a specific appearance under a microscope (granuloma) and contains calcium deposits. Because it usually takes some time for calcium to be deposited in a granuloma, it is generally assumed that a calcified granuloma is an old granuloma, or an old area of inflammation. For example, a calcified granuloma in the lung may be due to tuberculosis contracted years earlier that is now inactive and dormant.