Captopril-Hydrochlorothiazide

Captopril-Hydrochlorothiazide is a combination medication used to treat the symptoms of High Blood Pressure (Hypertension). 

• Captopril-Hydrochlorothiazide is available under the following different brand names: Capozide

Common side effects of Captopril-Hydrochlorothiazide include:

• Cough,
• Mild itching,
• Rash,
• Joint pain,
• Numbness in the hands or feet,
• Decreased sense of taste, and
• Flushing (warmth, redness, or tingly feeling)

Serious side effects of Captopril-Hydrochlorothiazide include:

• Hives,
• Difficulty breathing,
• Swelling of the face, lips, tongue, or throat,
• Severe stomach pain,
• Lightheadedness,
• Eye pain,
• Vision problems,
• Little or no urinating,
• Chest pain,
• Pounding heartbeats,
• Fluttering in the chest,
• Swelling,
• Weight gain,
• Shortness of breath,
• Pale skin,
• Easy bruising,
• Unusual bleeding,
• Sudden weakness,
• Ill feeling,
• Fever,
• Chills,
• Sore throat,
• Mouth sores,
• Trouble swallowing,
• Nausea,
• Slow or unusual heart rate,
• Weakness,
• Loss of movement,
• Leg cramps,
• Constipation,
• Irregular heartbeats,
• Increased thirst or urination,
• Numbness or tingling,
• Muscle weakness or limp feeling,
• Headache,
• Confusion,
• Slurred speech,
• Severe weakness,
• Vomiting,
• Loss of coordination,
• Feeling unsteady,
• Fever,
• Burning in the eyes,
• Skin pain, and
• Red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling

Rare side effects of Captopril-Hydrochlorothiazide include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Tablet

• 25 mg/15 mg
• 25 mg/25 mg
• 50 mg/15 mg
• 50 mg/25 mg

Hypertension

Adult dosage

• Initial: 25 mg captopril/15 mg hydrochlorothiazide orally once a day; not to exceed 150 mg captopril/50 mg chlorothiazide
• Increase either or both components based on clinical response every 6 weeks

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Captopril-Hydrochlorothiazide has severe interactions with the following drugs
  • aliskiren
  • sacubitril/valsartan
• Captopril-Hydrochlorothiazide has serious interactions with at least 55 other drugs.
• Captopril-Hydrochlorothiazide has serious interactions with at least 308 other drugs.
• Captopril-Hydrochlorothiazide has serious interactions with at least 165 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to either component or sulfonamides
• History of hereditary or idiopathic angioedema
• Coadministration of neprilysin inhibitors (.g, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of switching to or from sacubitril/valsartan
• Bilateral renal artery stenosis or anuria
• Do not coadminister aliskiren in patients with diabetes

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Captopril-Hydrochlorothiazide?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Captopril-Hydrochlorothiazide?”

Cautions

• Excessive hypotension if concomitant diuretics, hypovolemia, hyponatremia
• Risk of hyperkalemia, especially in patients with renal impairment, DM, or those taking concomitant K+-elevating drugs
• Dual blockade renin-angiotensin system with ARBs, ACE inhibitors, or aliskiren associated with increased risk for hypotension, hyperkalemia, and renal function changes (including acute renal failure) compared to monotherapy
• DM, fluid or electrolyte imbalance, hyperuricemia, or gout, SLE, liver disease, renal disease
• May aggravate digitalis toxicity
• Sensitivity reactions may occur with or without a history of allergy or asthma
• Aortic stenosis/ hypertrophic cardiomyopathy
• Biliary cirrhosis or biliary obstruction
• Myelosuppression
• Blood levels do not correlate with BP response
• Causes false positive urine acetone
• Risk of male sexual dysfunction
• Avoid concomitant use of lithium
• Acute transient myopia and acute angle-closure glaucoma have been reported, particularly with a history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide)

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during the 1st trimester; Use in LIFE-THREATENING emergencies when no safer drug is available during 2nd and 3rd trimester
• Lactation
  • Excreted in breast milk, use caution