Carboprost Tromethamine

Carboprost Tromethamine is a prescription medication used to treat Refractory Postpartum Uterine Bleeding and for abortion.  

• Carboprost Tromethamine is available under the following different brand name: Hemabate.

Adult dosage

Injectable solution

• 250mcg/mL

Abortion 

Adult dosage

• Initial: 250 mcg IM; then repeat as needed every 1.5-3.5 hours, or
• An initial, optional test dose of 100 mcg IM; then increase the dose to 500 mcg if the response is inadequate with 250 mcg doses
• No more than 1200 mcg total dose or 2 days of continuous administration

Refractory Postpartum Uterine Bleeding

Adult dosage

• Initial 250 mcg IM, repeat as needed every 15-90 minutes
• No more than 2000 mcg or 8 doses

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”.

Common side effects of Carboprost Tromethamine include:

• mild nausea, 
• vomiting, 
• diarrhea, 
• mild fever, 
• chills, 
• flushing (warmth, redness, or tingly feeling), 
• cough, 
• hiccups, 
• headache, and
• mild pelvic pain or menstrual-type cramps

Serious side effects of Carboprost Tromethamine include:

• hives, 
• difficult breathing, 
• swelling of the face, lips, tongue, or throat, 
• severe pelvic pain, 
• cramping, 
• vaginal bleeding, 
• lightheadedness, 
• shortness of breath, 
• severe nausea, 
• vomiting, 
• diarrhea, 
• severe headache, 
• blurred vision, 
• buzzing in the ears, 
• anxiety, 
• confusion, and 
• chest pain

Rare side effects of Carboprost Tromethamine include:

• none 

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Carboprost Tromethamine has severe interactions with no other drugs.
• Carboprost Tromethamine has serious interactions with no other drugs.
• Carboprost Tromethamine has moderate interactions with the following drugs:
  • eluxadoline
  • oxytocin
• Carboprost Tromethamine has minor interactions with no other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the drugs you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Contraindications

• Hypersensitivity 
• Acute pelvic inflammatory disease
• Active cardiac, pulmonary, renal, or hepatic disease

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Carboprost Tromethamine?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Carboprost Tromethamine?”

Cautions

• History of glaucoma or raised IOP
• Asthma, hypertension/hypotension, cardiovascular disease
• Transient fever observed with treatment possibly as a result of carboprost’s effect on hypothalamic thermoregulation
• Caution in patients with anemia, jaundice, renal impairment, hepatic impairment diabetes, or epilepsy 
• To decrease GI side effects pretreatment or concomitant use with antiemetic and antidiarrheal agents recommended
• Not for IV
• Rare cases of cardiovascular collapse were reported with prostaglandins

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during pregnancy.
• Lactation: Excretion in milk unknown.