Castor Oil/Trypsin

Castor oil/trypsin is used for the treatment of skin ulcers and wound healing.

Castor oil/trypsin is available under the following different brand names: Granulex, Xenaderm, and Optase.

Dosages of Castor Oil/Trypsin:

Dosage Forms and Strengths

Ointment

• (788mg/g)/(90USP)

Spray/Aerosol

• (788mg/g)/(0.12mg)
• (650mg/g)/(0.1mg)

Dosage Considerations – Should be Given as Follows:

Treatment of Skin Ulcers and Wound Healing

• Ointment: Apply thin film every 12 hours or more often as needed
• Spray/aerosol: Apply every 12 hours or more often as needed

Administration

May be left undressed or bandaged with appropriate dressing

Safety and efficacy not established in pediatric patients

Side effects of castor oil/trypsin include:

• Temporary "burning" sensation upon application
• Skin irritation

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

• Castor oil/trypsin has no listed severe interactions with other drugs.
• Castor oil/trypsin has no listed serious interactions with other drugs.

Moderate interactions of castor oil/trypsin include:

• deflazacort
• silver nitrate

Castor oil/trypsin has no listed mild interactions with other drugs.
 

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

This medication contains castor oil/trypsin. Do not take Granulex, Xenaderm, or Optase if you are allergic to castor oil/trypsin or any ingredients contained in this drug.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• Hypersensitivity

Effects of Drug Abuse

• No information is available

Short-Term Effects

• See "What Are Side Effects Associated with Using Castor Oil/Trypsin?”

Long-Term Effects

• See "What Are Side Effects Associated with Using Castor Oil/Trypsin?”

Cautions

• Do not use on fresh arterial clots
• Avoid spraying on eyes
• Do not expose aerosol formulation to flame or high temperatures
• Spray is flammable
• In presence of zinc or hemoglobin deficiency wound healing may be delayed

Pregnancy and Lactation

There is no information available regarding the use of castor oil/trypsin during pregnancy or while breastfeeding. Consult your doctor.