Choline Magnesium Trisalicylate

Choline Magnesium Trisalicylate is a prescription medication used to reduce pain and inflammation caused by conditions such as arthritis. It is also used to treat fever in adults.

• Choline Magnesium Trisalicylate is available under the following different brand names: Trilisate ASA combination

Common side effects of Choline Magnesium Trisalicylate include:

• upset stomach
• heartburn
• nausea
• vomiting
• diarrhea
• constipation
• dizziness
• drowsiness
• lack of energy
• headache

Serious side effects of Choline Magnesium Trisalicylate include:

• chest painweakness
• shortness of breath
• slurred speech
• problems with vision or balance
• sudden numbness or weakness, especially on one side of the body
• bloody or tarry stools
• coughing up blood or vomit that looks like coffee grounds
• blood in the urine, urinating more or less than usual
• hearing problems, ringing in the ears
• severe stomach pain, ongoing nausea or vomiting, jaundice (yellowing of the skin or eyes)
• easy bruising or bleeding, unusual weakness
• fast or pounding heartbeats, light-headedness

Rare side effects of Choline Magnesium Trisalicylate include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Liquid

• 500 mg/5mL (294 mg choline salicylate, 362 mg magnesium salicylate)

Tablet

• 500 mg (294 mg choline salicylate, 362 mg magnesium salicylate)
• 750 mg (440 mg choline salicylate, 544 mg magnesium salicylate)
• 1000 mg (587 mg choline salicylate, 725 mg magnesium salicylate)

Osteoarthritis

Adult dosage

• 1000-3000 mg orally every 8-12 hours

Geriatric dosage

• 750 mg orally every 8 hours

Rheumatoid arthritis

Adult dosage

• 1000-3000 mg orally every 8-12 hours

Geriatric dosage

• 500-1500 mg orally every 8-12 hours

Mild to moderate pain

Pediatric dosage

• Children weighing below 37 kg: 50 mg/kg orally divided every 12 hours.
• Children weighing above 37 kg: 2250 mg orally divided every 12 hours.

Fever

Adult dosage

• 1000-1500 mg orally every 12 hours.

Pediatric dosage

• Children weighing below 37 kg: 50 mg/kg orally divided every 12 hours.
• Children weighing above 37 kg: 2250 mg orally divided every 12 hours

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, healthcare provider, or pharmacist first.

• Choline Magnesium Trisalicylate has severe interactions with the following drug:
  • dichlorphenamide
• Choline Magnesium Trisalicylate has serious interactions with the following drugs:
  • benazepril
  • captopril
  • enalapril
  • fosinopril
  • ketorolac
  • lisinopril
  • measles, mumps, rubella, and varicella vaccine, live
  • methotrexate
  • moexipril
  • pemetrexed
  • perindopril
  • quinapril
  • ramipril
  • trandolapril
  • varicella virus vaccine live
  • warfarin
• Choline Magnesium Trisalicylate has moderate interactions with at least 220 other drugs.
• Choline Magnesium Trisalicylate has minor interactions with at least 120 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• Absolute: Bleeding disorders, chronic advanced renal insufficiency, gastrointestinal (GI) hemorrhage, hemorrhagic diathesis, salicylate allergy
• Relative: Erosive gastritis, GI ulcer, NOS

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Choline Magnesium Trisalicylate?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Choline Magnesium Trisalicylate?”

Cautions

• Anemia, gout, hepatic function impairment, hypertension, hypoprothrombinemia, nasal polyps, renal function impairment, thyrotoxicosis, vitamin K deficiency
• Use of salicylates in pediatric patients with varicella or influenza-like illness is associated with increased incidence of Reye's Syndrome

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during pregnancy; use in LIFE-THREATENING emergencies when no safer drug is available if used for prolonged periods or near term
• Lactation
  • Excreted in human breast milk; adverse effect on the nursing infant