Clonidine-Chlorthalidone

Clonidine-Chlorthalidone is a combination medication used for the treatment of hypertension. 

• Clonidine-Chlorthalidone is available under various brand names: Clorpres

Common side effects of Clonidine-Chlorthalidone include:

• drowsiness, dizziness;
• feeling tired or irritable;
• dry mouth;
• constipation, loss of appetite; or
• sleep problems (insomnia), nightmares.

Serious side effects of Clonidine-Chlorthalidone include:

• hives,
• difficult breathing,
• swelling of the face, lips, tongue, or throat,
• severe chest pain, shortness of breath, irregular heartbeats;
• a very slow heart rate; or
• a light-headed feeling.

Rare side effects of Clonidine-Chlorthalidone include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult  dosage

Tablet

• 0.1 mg/15 mg
• 0.2 mg/15 mg
• 0.3 mg/15 mg

Hypertension

Adult dosage

• Usual dose: 0.1-0.3 mg/15 mg orally every day or every 12 hours
• Maximum: 0.6 mg/30 mg orally every day

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Clonidine-Chlorthalidone has severe interactions with no other drugs.
• Clonidine-Chlorthalidone has serious interactions with at least 74 other drugs.
• Clonidine-Chlorthalidone has moderate interactions with at least 262 other drugs.
• Clonidine-Chlorthalidone has minor interactions with atleast 152 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to either component or sulfonamide derivatives

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Clonidine-Chlorthalidone?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Clonidine-Chlorthalidone?”

Cautions

• Bronchospastic disease
• DM, hyperuricemia or gout, hypotension, SLE
• Chlorthalidone may cause fluid or electrolyte imbalance including hyponatremia, hypochloremic alkalosis, or hypokalemia
• History of depression
• Liver disease
• May aggravate digitalis toxicity
• Patients allergic to sulfa may show cross-sensitivity
• May impair the ability to perform hazardous tasks
• Risk of male sexual dysfunction
• Renal impairment
  • Severe coronary insufficiency, recent MI, conduction disturbances, cerebrovascular disease, chronic renal failure, Raynaud's disease, thromboangiitis obliteran
  • Sudden cessation of clonidine treatment has resulted in subjective symptoms such as nervousness, agitation and headache, accompanied or followed by a rapid rise in blood pressure and elevated catecholamine concentrations in the plasma

Pregnancy & Lactation

• Use with caution if the benefits outweigh the risks during pregnancy
• Lactation
  • Excreted in breast milk, use caution