Cortisone: A naturally occurring adrenocorticoid hormone that is produced in minute amounts by the adrenal gland. Synthetic cortisone is also available; it is metabolized by the body into cortisol. Uses for synthetic oral, intramuscular, and intravenous cortisone medications include treatment of adrenocortical deficiency and treatment of conditions associated with inflammation. A popular topical form is known as hydrocortisone cream.
