Cyclopentolate-Phenylephrine-IV

Cyclopentolate-Phenylephrine is a combination medication used to dilate pupils in preparation for an eye exam.

• Cyclopentolate-Phenylephrine is available under the following different brand names: Cyclomydril

Common side effects of Cyclopentolate-Phenylephrine include:

• increased eye pressure
• burning/irritation upon instillation
• eye sensitivity to light
• blurred vision
• superficial punctate keratitis (eye redness, watery eyes, sensitivity to light, decreased vision)

Serious side effects of Cyclopentolate-Phenylephrine include:

• blurred vision, tunnel vision, or seeing halos around lights
• eye pain
• fast heart rate, severe headache, pounding in the neck or ears, anxiety
• fever
• little or no urinating
• flushing (warmth, redness, or tingly feeling)
• severe constipation
• weak or shallow breathing

Rare side effects of Cyclopentolate-Phenylephrine include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Ophthalmic solution

• 0.2%/1%

Mydriasis/cycloplegia diagnosis

Adult and pediatric dosage

• 1-2 drops in the conjunctival sac every 5-10 minutes, not to exceed 3 times

Dosage Considerations – Should be Given as Follows:

• See "Dosages"

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, healthcare provider, or pharmacist first.

• Cyclopentolate-Phenylephrine has severe interactions with the following drugs:
  • iobenguane I 123
  • isocarboxazid
  • linezolid
  • phenelzine
  • procarbazine
  • selegiline transdermal
  • tranylcypromine
• Cyclopentolate-Phenylephrine has serious interactions with at least 27 other drugs
• Cyclopentolate-Phenylephrine has moderate interactions with at least 169 other drugs
• Cyclopentolate-Phenylephrine has minor interactions with the following drugs:
  • alfuzosin
  • asenapine
  • desmopressin
  • doxazosin
  • eucalyptus
  • moxisylyte
  • phenoxybenzamine
  • phentolamine
  • prazosin
  • sage
  • silodosin
  • terazosin

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• Untreated narrow-angle glaucoma
• Hypersensitivity to any component

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Cyclopentolate-Phenylephrine?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Cyclopentolate-Phenylephrine?”

Cautions

• Reduce dose if used within 21 days of monoamine oxidase inhibitors or tricyclic antidepressants
• Wait 5 minutes between multiple drops (no more than three drops needed)
• May cause false-normal tonometry readings, so tonometry should be performed before phenylephrine is administered
• Restrict to short-term use (safety and efficacy of long-term use not established)
• Use caution in Down syndrome (predisposed to angle-closure glaucoma)
• Remove contact lenses before administration and wait 15 minutes before reinserting
• The elderly may be predisposed to increased intraocular pressure
• May result in psychotic reactions and behavioral disturbances in children 30-45 minutes after instillation
• Minimize absorption by using one drop of solution per eye and applying pressure

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during pregnancy
• Lactation
  • Unknown if excreted in breast milk, so use caution