Dyspnea: Difficult or labored breathing; shortness of breath. Dyspnea is a sign of serious disease of the airway, lungs, or heart. The onset of dyspnea should not be ignored; it is reason to seek medical attention. From Lung Disease/COPD Resources Featured Centers What Are the Best PsA Treatments for You?Understanding Biologics 10 Things People With Depression Wish You Knew