Eprosartan-Hydrochlorothiazide

Eprosartan-Hydrochlorothiazide is a combination medication used for the treatment of hypertension (high blood pressure).

• Eprosartan-Hydrochlorothiazide is available under the following different brand names: Teveten HCT, Teveten Plus

Common side effects of Eprosartan-Hydrochlorothiazide include:

• stomach pain
• back pain
• drowsiness
• headache
• runny or stuffy nose
• sore throat
• dry cough

Serious side effects of Eprosartan-Hydrochlorothiazide include:

• chest pain or tightness
• increased or decreased urination or not urinating at all
• eye pain
• vision problems
• shortness of breath
• fast or irregular heartbeat
• fainting
• fever

Rare side effects of Eprosartan-Hydrochlorothiazide include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, light-headedness, or passing out

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Tablet

• 600 mg/12.5 mg
• 600 mg/25 mg

Hypertension

Adult dosage

• 600 mg/12.5 mg to 600 mg/25 mg orally every day

Dosage Considerations – Should be Given as Follows:

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, healthcare provider, or pharmacist first.

• Eprosartan-Hydrochlorothiazide has severe interactions with the following drugs:
  • aliskiren
  • sparsentan
• Eprosartan-Hydrochlorothiazide has serious interactions with at least 23 other drugs
• Eprosartan-Hydrochlorothiazide has moderate interactions with at least 219 other drugs
• Eprosartan-Hydrochlorothiazide has minor interactions with at least 126 other drugs

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• Hypersensitivity to eprosartan, hydrochlorothiazide, or sulfonamides
• Pregnancy (2nd/3rd trimesters): Significant risk of fetal/neonatal morbidity and mortality
• Anuria
• Do not coadminister with aliskiren in patients with diabetes mellitus

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Eprosartan-Hydrochlorothiazide?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Eprosartan-Hydrochlorothiazide?”

Cautions

• Acute transient myopia and acute angle-closure glaucoma has been reported, particularly with history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide)
• Not for initial treatment
• Electrolyte disturbances may occur
  • Hyperkalemia, particularly when coadministered with potassium-sparing diuretics, potassium supplements, or salt substitutes; concurrent therapy with hydrochlorothiazide may reduce the frequency of this effect
• Photosensitivity may occur
• Hypotension may occur in patients who are salt or volume depleted (correct the volume depletion especially in patients receiving high dose diuretics)
• Dual blockade of the renin angiotensin system with ARBs, ACE inhibitors, or aliskiren associated with increased risk for renal function changes (including acute renal failure) compared to monotherapy
• Caution in aortic mitral stenosis, hepatic impairment, hypercholesterolemia, hypercalcemia, parathyroid disease, pre-existing renal insufficiency, systemic lupus erythematosus, bilateral renal artery stenosis or anuria
• Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides
• Thiazides may decrease urinary calcium excretion

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during first trimester; use in life-threatening emergencies when no safer drug available during second and third trimesters
• Lactation
  • Excretion in milk unknown/not recommended