Eptinezumab

Eptinezumab is a prescription medication used for preventive treatment of migraine.

• Eptinezumab is available under the following different brand names: Vyepti, eptinezumab-jjmr

Common side effects of Eptinezumab include:

• Stuffy nose and scratchy throat
• Allergic reactions
• Serious side effects of Eptinezumab include:
• Allergic reactions like rash, swelling of the face, lips, tongue, or throat, trouble breathing, hives and redness in the face

Rare side effects of Eptinezumab include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Injectable solution

• 100 mg/mL

Migraine

Adult dosage

• 100 mg Intravenous every 3 months
• Some patients may benefit from a 300-mg Intravenous dose every 3 months

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Eptinezumab has no noted severe interactions with any other drugs.
• Eptinezumab has no noted serious interactions with any other drugs.
• Eptinezumab has no noted moderate interactions with any other drugs.
• Eptinezumab has no noted minor interactions with any other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

Hypersensitivity to eptinezumab-jump or any of the excipients

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Eptinezumab?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Eptinezumab?”

Cautions

• Hypersensitivity reactions, including angioedema, urticaria, anaphylaxis, facial flushing, dyspnea, and rash, have occurred; if a hypersensitivity reaction occurs, consider discontinuing treatment and institute appropriate therapy

Pregnancy and Lactation

• There are no adequate data on developmental risks associated with use in pregnant women
• No adverse developmental effects were observed following the administration of eptinezumab-jump to pregnant animals at doses greater than those used clinically
• Clinical considerations
  • Published data have suggested that women with migraine may be at increased risk of preeclampsia and gestational hypertension during pregnancy
• Lactation
  • Data are not available regarding the presence in human milk, effects on breastfed infants, or effects on milk production