Esomeprazole naproxen

Esomeprazole and naproxen is a combination prescription medication used for relieving pain associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. The esomeprazole in this medicine helps reduce the risk of stomach ulcers in people who may be at risk for them while receiving treatment with an NSAID.

• Esomeprazole and naproxen are available under various brand names: Vimovo

Common side effects of Esomeprazole and naproxen include:

• stomach discomfort; or
• diarrhea.

Serious side effects of Esomeprazole and naproxen include:

• signs of an allergic reaction (hives, sneezing, runny or stuffy nose, wheezing, difficult breathing, swelling in the face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling);
• signs of a heart attack or stroke: chest pain spreading to the jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath;
• severe stomach pain, watery or bloody diarrhea;
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• heart problems-- swelling, rapid weight gain, feeling short of breath;
• kidney problems--little or no urination, blood in the urine;
• liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes);
• low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in the hands and feet, cough or choking feeling;
• low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
• new or worsening symptoms of lupus--joint pain, and a skin rash on the cheeks or arms that worsens in sunlight.

Rare side effects of Esomeprazole and naproxen include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Severe eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
• Severe heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Tablet

• 20 mg/375 mg
• 20 mg/500 mg

Rheumatoid Arthritis

Adult dosage

• 1 tablet orally twice daily at least 30 min before a meal

Osteoarthritis

Adult dosage

• 1 tablet orally twice daily at least 30 min before a meal

Ankylosing Spondylitis

Adult dosage

• 1 tablet orally twice daily at least 30 min before a meal

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Esomeprazole and naproxen have severe interactions with the following drugs:
  • erlotinib
  • mavacamten
  • nelfinavir
  • rilpivirine
• Esomeprazole and naproxen have serious interactions with at least 56 other drugs.
• Esomeprazole and naproxen have moderate interactions with at least 303 other drugs.
• Esomeprazole and naproxen have minor interactions with at least 110 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Allergic to medicines like esomeprazole, such as lansoprazole, omeprazole, pantoprazole, rabeprazole, Dexilant, Nexium, Prevacid, Protonix, and others
• asthma attack or severe allergic reaction after taking aspirin or an NSAID; or;
• HIV medicine that contains rilpivirine (Complera, Edurant, Odefsey)
• Children younger than 12 years old or weighing less than 38 kilograms

Effects of drug abuse

• none.

Short-Term Effects

• See “What Are Side Effects Associated with Using Esomeprazole and naproxen?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Esomeprazole and naproxen?”

Cautions

• Naproxen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Naproxen may also cause stomach or intestinal bleeding, which can be fatal.
• Esomeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.
• Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.
• Esomeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.
• You may be more likely to have a broken bone while taking this medicine long-term or more than once per day.
• Naproxen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
• Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using naproxen, especially in older adults.
• You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.
• This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.
• Avoid drinking alcohol. It may increase your risk of stomach bleeding.
• Taking regular naproxen together with esomeprazole (Nexium) will not work the same way as taking a combination of esomeprazole and naproxen (Vimovo). Do not substitute this medicine with over-the-counter products.
• Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to naproxen (such as aspirin, ibuprofen, or ketoprofen).

Pregnancy and Lactation

• Taking naproxen during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Lactation

• It may not be safe to breastfeed while using this medicine. Ask your doctor about any risks.