Famotidine Ibuprofen

Famotidine and Ibuprofen are combination medications used to treat the symptoms of arthritis. Famotidine helps reduce the risk of ulcers in the stomach or intestines that can be caused by long-term use of ibuprofen.

• Famotidine and Ibuprofen are available under various brand names: Duexis

Common side effects of Famotidine and Ibuprofen include: 

• nausea, stomach pain.
• diarrhea, constipation; or
• headache

Serious side effects of Famotidine and Ibuprofen include:

• sneezing, runny, or stuffy nose; wheezing or trouble breathing, swelling in the face or throat, or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
• signs of a heart attack or stroke: chest pain spreading to the jaw or shoulder, sudden numbness, or weakness on one side of the body, slurred speech, leg swelling, or feeling short of breath.
• changes in the vision.
• the first sign of any skin rash, no matter how mild.
• fever, headache, neck stiffness, increased sensitivity to light, nausea, vomiting, confusion, and drowsiness.
• severe headache, blurred vision, pounding in the neck or ears.
• little or no urination.
• swelling, and rapid weight gain.
• liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands, and feet; or
• signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Rare side effects of Famotidine and Ibuprofen include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Tablet

• 800 mg/26.6 mg

Osteoarthritis, rheumatoid arthritis

Adult dosage

• Oral: One tablet (ibuprofen 800 mg/famotidine 26.6 mg) 3 times daily.

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Famotidine and Ibuprofen have severe interactions with no other drugs.
• Famotidine and Ibuprofen have serious interactions with the following drugs:
  • atazanavir
  • bosutinib
  • dapsone
  • dasatinib
  • digoxin
  • indinavir
  • itraconazole
  • ketoconazole
  • levoketoconazole
  • mefloquine
  • neratinib
  • nimodipine
  • nisoldipine
  • nitrendipine
  • pazopanib
  • pimozide
  • ponatinib
  • risedronate
  • secretin
  • vandetanib
• Famotidine and Ibuprofen have moderate interactions with at least 56 other drugs.
• Famotidine and Ibuprofen have minor interactions with the following drugs:
  • alendronate
  • aripiprazole
  • axitinib
  • blessed thistle
  • ceftibuten
  • cyanocobalamin
  • devil's claw
  • melphalan
  • metformin
  • phytoestrogens

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• hypersensitivity to famotidine or ibuprofen, 
• use during the perioperative period in the setting of CABG surgery
• asthma attack, or 
• severe allergic reaction after taking aspirin or an NSAID.

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Famotidine and Ibuprofen?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Famotidine and Ibuprofen?”

Cautions

• Ibuprofen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
• Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using famotidine and ibuprofen, especially in older adults.
• Ibuprofen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal.
• Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to ibuprofen (such as aspirin, ketoprofen, or naproxen).
• Avoid using other medications that contain ibuprofen.
• Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Pregnancy and Lactation

• Taking famotidine and ibuprofen during the last 3 months of pregnancy may harm the unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

Lactation

• It may not be safe to breastfeed while using this medicine. Ask your doctor about any risks.