uses
What is Tyvaso used for?Tyvaso is commonly used for pulmonary arterial hypertension (PAH), a condition where you have high blood pressure in the blood vessels that carry blood from your heart to your lungs.Tyvaso is also commonly used for people with high blood pressure in the lungs that is linked to inflammation in the lungs (interstitial lung disease). Tyvaso may also be used for other conditions as determined by your health care provider.For information about other forms of treprostinil, see treprostinil (Orenitram, Remodulin).How does Tyvaso work (mechanism of action)?Tyvaso works by widening the blood vessels in the lungs and the rest of the body, making it easier for blood to flow. This reduces strain on the heart and helps improve blood flow.How is Tyvaso supplied (dosage forms)?Brands and other namesTyvasoTyvaso DPIDosage forms and strengths16 mcg/cartridge, 32 mcg/cartridge, 48 mcg/cartridge, 64 mcg/cartridge, 80 mcg/cartridge inhalation powder 1.74 mg/2.9 mL (0.6 mg/mL) nebulizer solutionHow should I store Tyvaso?Inhaled Powder. Tyvaso dry powder for inhalation (DPI) comes in small, single-dose plastic cartridges. The cartridges come in blister strips. You will load a cartridge into a Tyvaso DPI inhaler for each dose. The following storage guidelines are recommended for Tyvaso DPI cartridges and inhalers.Cartridges in blister strips that are sealed and unopened can be stored at room temperature, between 68 F and 77 F (20 C and 25 C), for up to eight weeks, or in the refrigerator, between 36 F and 46 F (2 C and 8 C), until the expiration date. If stored at room temperature, the medicine may be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when you’re transporting it. If you refrigerate it, take it out and leave it at room temperature for 10 minutes before you use it.Cartridges in blister strips that are opened should be kept at room temperature, between 68 F and 77 F (20 C and 25 C), for up to three days. The medicine may be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when you’re transporting it. You should not put opened blister strips back in the refrigerator.The Tyvaso DPI inhaler can be stored at room temperature or in the refrigerator, between 36 F and 77 F (2 C and 25 C). If it’s refrigerated, take the inhaler out and leave it at room temperature for 10 minutes before you use it.Nebulizer Solution. Tyvaso nebulizer solution comes as a liquid in small plastic containers (ampules). The ampules come in a foil pouch. Keep the medicine in the foil pouch to protect it from light. Store the unopened foil pouch at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when you’re transporting it. Store it in a cool, dry place. Once the foil pouch is opened, the ampules should be used within seven days.Â
how to use
liquid or powder that is inhaled
drug interactions
Does Tyvaso interact with foods or drinks?There are no known interactions between Tyvaso and foods or drinks.It is unknown if drinking alcohol will affect Tyvaso. The risk of dizziness may be increased if you drink alcohol while using Tyvaso.Does Tyvaso interact with other medicines (drug interactions)?Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.In particular, make sure that you discuss if you are using any of the following before using Tyvaso.Gemfibrozil (Lopid), which is a medicine for high cholesterolRifampin (Rifadin), which is a medicine used to treat an infection called tuberculosisAny other medicine that contains treprostinil, such as Orenitram or RemodulinSome other medicines may alter the blood levels of Tyvaso. Tell your health care provider about all medicines that you take or have recently taken.This may not be a complete list of medicines that can interact with Tyvaso. Always check with your health care provider.Â
side effects
What are the most common side effects of Tyvaso?The most common side effects of Tyvaso are listed below. These side effects may vary, depending on the specific product you are prescribed. Tell your health care provider if you have any of these side effects that bother you.CoughHeadacheNauseaDizziness or faintingFlushingThroat pain or irritationDiarrheaThere may be other side effects of Tyvaso that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.What are the serious side effects of Tyvaso?While less common, the most serious side effects of Tyvaso are described below, along with what to do if they happen.Severe Allergic Reactions. Tyvaso may cause allergic reactions, which can be serious. Stop using Tyvaso and get help right away if you have any of the following symptoms of a serious allergic reaction.Breathing problems or wheezing that are worse than usualRacing heartFever or general ill feelingSwollen lymph nodesSwelling of the face, lips, mouth, tongue, or throatTrouble swallowing or throat tightnessItching, skin rash, or pale red bumps on the skin called hivesNausea or vomitingDizziness, feeling lightheaded, or faintingStomach crampsJoint painLow Blood Pressure (Hypotension). Tyvaso may cause low blood pressure. If you feel faint or dizzy, lie down. Tell your health care provider right away if you have any of the following symptoms of low blood pressure.Dizziness, feeling lightheaded, or faintingConfusionFeeling weak or tiredSudden Breathing Problems. Tyvaso may cause the muscles around the airways to tighten (bronchospasm), which can be serious. The risk of this side effect may be higher if you also have breathing problems such as asthma or chronic obstructive pulmonary disease (COPD). Stop using Tyvaso and get help right away if you have trouble breathing that is sudden and worse than usual.Bleeding. Tyvaso can prevent blood cells from clumping together (clotting), which can raise your risk of bleeding. Tell your health care provider if you have unusual bleeding or bruising while using Tyvaso.Â
overdose and misseddose
What should I do if I accidentally use too much Tyvaso?If you or someone else has used too much Tyvaso, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.What should I do if I miss a dose of Tyvaso?If you miss a dose, use it as soon as you can. Then continue with your regular treatment schedule. Do not use double or extra doses.
warnings and Precautions
Who should not use Tyvaso?Allergies to Ingredients. People who are allergic to any of the following should not use Tyvaso.TreprostinilTyvasoTyvaso DPIAny of the ingredients in the specific product dispensedYour pharmacist can tell you all of the ingredients in Tyvaso.What should I know about Tyvaso before using it?Do not use Tyvaso unless it has been prescribed to you by a health care provider. Use it as prescribed.Do not share Tyvaso with other people, even if they have the same condition as you. It may harm them.Keep Tyvaso out of the reach of children. Since this medicine may be kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.There are two forms of Tyvaso available, an inhaled powder and a nebulizer solution. (A nebulizer is a device that turns a liquid into a mist that you inhale.) Read and follow the instructions for the product you have and make sure you understand how to store, prepare, use, and clean it properly. It is recommended to keep backup supplies on hand, in case it does not work the way it should.If you use Tyvaso nebulizer solution, avoid getting the medicine on your skin or in your eyes. If eye or skin contact occurs, rinse with water right away. Do not put other medicines in the Tyvaso Inhalation System, and do not mix Tyvaso with other medicines. Throw away any Tyvaso remaining in the nebulizer at the end of the day. If you use Tyvaso DPI, throw away the inhaler after seven days of use and replace it with a new one. Do not swallow Tyvaso. What should I tell my health care provider before using Tyvaso?Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Tyvaso is right for you.In particular, make sure that you discuss any of the following.Other Medicines and Supplements. Tyvaso may interact with other medicines and supplements. Before using Tyvaso, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.Current and Past Health Conditions. Tell your health care provider if you have any of the following.Other breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD)Liver problemsLow blood pressureBleeding problemsPregnancy. It is not known if or how Tyvaso could affect pregnancy or harm an unborn baby. Tell your health care provider if you are pregnant or plan to become pregnant.Breastfeeding. It is not known if Tyvaso passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.How can I get more information about Tyvaso?For more information about Tyvaso, you can visit the drugmaker’s website at www.tyvaso.com or call them at 844-864-8437.
about
Tyvaso is an inhaled medicine used to treat high blood pressure in the lungs. It works by widening blood vessels in the lungs to make it easier for blood to flow. Common side effects include coughing, headaches, nausea, diarrhea, flushing, and a sore throat. Less common, more serious side effects include low blood pressure, sudden breathing problems, and bleeding. Tyvaso is available in two forms: an inhaled powder and a nebulizer solution.