uses
What is Krystexxa used for?Krystexxa (pegloticase) is commonly used to treat gout, which is a form of arthritis caused by too much uric acid in your blood and joints. Krystexxa may be used when other medicines for gout, such as allopurinol, cannot be safely used or have not worked well enough.Krystexxa may also be used for other conditions as determined by your health care provider.How does Krystexxa work (mechanism of action)?Krystexxa works by reducing the amount of uric acid in your body. If uric acid levels get too high, crystals can form in your joints and cause inflammation and pain (gout flares). By reducing uric acid levels, Krystexxa helps prevent gout flares.How is Krystexxa supplied (dosage forms)?Krystexxa is available in an injectable form that is given by a health care provider.How should I store Krystexxa?Krystexxa is usually given by a health care provider in a hospital or clinic. You will not store it at home.
how to use
liquid that is injected into a blood vessel
drug interactions
Does Krystexxa interact with foods or drinks?There are no known interactions between Krystexxa and foods or drinks.It is unknown if drinking alcohol will affect Krystexxa, but alcohol may worsen gout. It is best to limit the amount of alcohol that you drink.Does Krystexxa interact with other medicines (drug interactions)?Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.In particular, make sure that you discuss if you are using a uric acid-lowering medicine, such as allopurinol, febuxostat (Uloric), or probenecid, before using Krystexxa.This may not be a complete list of medicines that can interact with Krystexxa. Always check with your health care provider.
side effects
What are the most common side effects of Krystexxa?The most common side effects of Krystexxa are listed below. Tell your health care provider if you have any of these side effects that bother you.Gout flares (see below)Infusion reactions (see below)Joint painNausea and vomitingTirednessBruisingSore throatConstipationChest painThere may be other side effects of Krystexxa that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.What are the serious side effects of Krystexxa?While less common, the most serious side effects of Krystexxa are described below, along with what to do if they happen.Severe Allergic Reactions. Krystexxa may cause allergic reactions, which can be serious. Stop using Krystexxa and get help right away if you have any of the following symptoms of a serious allergic reaction.Breathing problems or wheezingRacing heartFever or general ill feelingSwollen lymph nodesSwelling of the face, lips, mouth, tongue, or throatTrouble swallowing or throat tightnessItching or skin rashBumps on the skin called hives that can be red, pink, white, or brown depending on your skin toneNausea or vomitingDizziness, feeling lightheaded, or faintingStomach crampsJoint painInfusion Reactions. Krystexxa can cause reactions that can be serious when it is given to you. Your infusion may need to be slowed or stopped if you have these reactions. Tell your health care provider right away if you have any of the following symptoms when you get your infusion or shortly thereafter.RashSkin rednessTrouble breathingFlushingItchingChest painGout Flares. Krystexxa may increase your gout flares before making your symptoms better. It may take a few months to reduce uric acid levels enough to control your gout flares. Follow your health care provider’s recommendations, which may include taking other medicines to help reduce your gout flares.
overdose and misseddose
What should I do if I accidentally use too much Krystexxa?If you or someone else has used too much Krystexxa, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.What should I do if I miss a dose of Krystexxa?If you miss an appointment to get your Kristexxa dose, call to make another appointment as soon as possible.Â
warnings and Precautions
Who should not use Krystexxa?Allergies to Ingredients. People who are allergic to any of the following should not use Krystexxa.KrystexxaPegloticaseAny of the ingredients in the specific product dispensedYour pharmacist can tell you all of the ingredients in Krystexxa.G6PD Deficiency. People with glucose-6-phosphate dehydrogenase (G6PD) deficiency should not use Krystexxa. Using Krystexxa if you have G6PD deficiency puts you at risk for hemolysis and methemoglobinemia, which are serious conditions that affect red blood cells. Your health care provider may run tests to determine if you have G6PD deficiency before starting treatment with Krystexxa.What should I know about Krystexxa before using it?Krsytexxa is usually given to you through an infusion into a vein by a health care provider in a hospital or clinic. You may want to use a calendar or an app to remind you of your appointments to receive Kystexxa.Your health care provider may prescribe medicines for you to take before you receive a dose of Krystexxa. Make sure to take these medicines as directed because they are meant to reduce your risk of having certain side effects.If you are being treated for gout, your symptoms may get worse before getting better while using Krystexxa. Do not stop using Krystexxa, and talk to your health care provider about managing gout flares while using Krystexxa.What should I tell my health care provider before using Krystexxa?Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Krystexxa is right for you.In particular, make sure that you discuss any of the following.Current and Past Health Conditions. Tell your health care provider if you have any of the following.High blood pressureHeart problems, including heart failurePrevious treatment with KrystexxaOther Medicines and Supplements. Krystexxa may interact with other medicines and supplements. Before using Krystexxa, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.Pregnancy. It is not known if or how Krystexxa could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.Breastfeeding. It is not known if Krystexxa passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should stop breastfeeding or stop Krystexxa.How can I get more information about Krystexxa?For more information about Krystexxa, you can visit the drugmaker’s website at www.krystexxa.com or call them at 833-469-4688.
about
Krystexxa is used to help prevent gout flares. It works by reducing the amount of uric acid in your body. Common side effects include nausea and vomiting, joint pain, and infusion reactions. Krystexxa is given as an infusion into your vein (IV) by a health care provider. Tell your health care provider right away if you notice any unusual symptoms when you get your infusion or afterward.Â