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Penciclovir (Denavir): Uses, Side Effects, Interactions & Pill Images

Penciclovir (Denavir)

uses

What is penciclovir used for?Penciclovir is commonly used to treat cold sores.Penciclovir may also be used for other conditions as determined by your healthcare provider.How does penciclovir work (mechanism of action)?Penciclovir is an antiviral medicine that stops the growth of herpes viruses and improves symptoms. It is important to note that penciclovir is not a cure. The herpes viruses remain in the body even if you do not have symptoms.How is penciclovir supplied (dosage forms)?Brands and other namesDenavirDosage forms and strengths1% topical creamHow should I store penciclovir?Penciclovir should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

how to use

cream that is applied to the skin

drug interactions

Does penciclovir interact with foods or drinks?There are no known interactions between penciclovir and foods or drinks.There are no known interactions between penciclovir and alcohol, but heavy drinking can slow your immune response and make it harder for your body to fight infection.Does penciclovir interact with other medicines (drug interactions)?There are no known interactions between penciclovir and other medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

side effects

What are the most common side effects of penciclovir?The most common side effects of penciclovir may include mild redness, irritation, or tingling where penciclovir is applied. Tell your healthcare provider if you have any of these side effects that bother you.There may be other side effects of penciclovir that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.What are the serious side effects of penciclovir?While less common, the most serious side effects of penciclovir are described below, along with what to do if they happen.Severe Allergic Reactions. Penciclovir may cause allergic reactions, which can be serious. Stop using penciclovir and get help right away if you have any of the following symptoms of a serious allergic reaction.Breathing problems or wheezingRacing heartFever or general ill feelingSwollen lymph nodesSwelling of the face, lips, mouth, tongue, or throatTrouble swallowing or throat tightnessItching, skin rash, or pale red bumps on the skin called hivesNausea or vomitingDizziness, feeling lightheaded, or faintingStomach crampsJoint pain

overdose and misseddose

What should I do if I accidentally use too much penciclovir?If you or someone else has used too much penciclovir, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.What should I do if I miss a dose of penciclovir?If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only use the next dose. Do not use double or extra doses.Â

warnings and Precautions

Who should not use penciclovir?Allergies to Ingredients. People who are allergic to any of the following should not use penciclovir.PenciclovirDenavirAny of the ingredients in the specific product dispensedYour pharmacist can tell you all of the ingredients in the specific penciclovir products they stock.What should I know about penciclovir before using it?Do not use penciclovir unless it has been prescribed to you by a healthcare provider. Use it as prescribed.Do not share penciclovir with other people, even if they have the same condition as you. It may harm them.Keep penciclovir out of the reach of children.You should start penciclovir as soon as possible when you first have cold sore symptoms, such as tingling, redness, or itching.Wash your hands with soap and water before and after applying this medicine.Penciclovir should only be applied on the lips and face. Do not apply this medicine in or near the eyes. Tell your healthcare provider if your cold sores do not get better or get worse during or after treatment.  What should I tell my healthcare provider before using penciclovir?Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if penciclovir is right for you.Weak Immune System. Tell your healthcare provider if you have a weak immune system before using penciclovir.Pregnancy. Penciclovir is not absorbed by the body and is not expected to reach the baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should use penciclovir while you are pregnant or trying to get pregnant. Breastfeeding. Penciclovir is not absorbed by the body and is not expected to reach the baby during breastfeeding. Tell your healthcare provider if you are or are planning to breastfeed. Your healthcare provider will advise you if you should use penciclovir while you are breastfeeding.Â

about

Penciclovir is used to treat cold sores. It comes as a cream that is applied to the affected area. Side effects are uncommon with penciclovir, but may include mild redness or irritation where the cream is applied.

Last reviewed on RxList: 04/14/2025