uses
What is Tri-Luma used for?Tri-Luma is commonly used to treat melasma on the face. Melasma is a condition where colored areas appear on skin that is exposed to sunlight.Tri-Luma may also be used for other conditions as determined by your healthcare provider.How does Tri-Luma work (mechanism of action)?Tri-Luma contains three medicines: fluocinolone, hydroquinone, and tretinoin. Fluocinolone belongs to a class of medicines called corticosteroids. It may block pigment (melanin) production in your skin while reducing the irritation caused by the other two medicines.Hydroquinone reduces the amount of pigment in your skin and is also believed to block pigment-producing cells. Tretinoin is believed to protect hydroquinone from breaking down and help it penetrate the outer skin so that it can reach the target skin cells. Tretinoin also accelerates skin turnover, which may help with pigment removal.How is Tri-Luma supplied (dosage forms)?Brands and other namesTri-LumaDosage forms and strengths0.01%/4%/0.05% topical creamHow should I store Tri-Luma?Tri-Luma should be stored in a refrigerator, at a temperature between 36 F and 46 F (2 C to 8 C). Keep the lid tightly closed. Do not freeze.
how to use
cream that is applied to the skin
drug interactions
Does Tri-Luma interact with foods or drinks?There are no known interactions between Tri-Luma and foods or drinks.It is unknown if drinking alcohol will affect Tri-Luma.Does Tri-Luma interact with other medicines (drug interactions)?Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, skin products, and other supplements you are using.In particular, make sure that you discuss if you are using or taking or using any medicine that makes you more sensitive to sunlight.This may not be a complete list of medicines that can interact with Tri-Luma. Always check with your healthcare provider.
side effects
What are the most common side effects of Tri-Luma?The most common side effects of Tri-Luma are listed below. Tell your healthcare provider if you have any of these side effects that bother you.Skin rednessSkin peeling (desquamation)Skin burning, dryness, itchingAcneThere may be other side effects of Tri-Luma that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.What are the serious side effects of Tri-Luma?While less common, the most serious side effects of Tri-Luma are described below, along with what to do if they happen.Severe Allergic Reactions. Tri-Luma may cause allergic reactions, which can be serious. Stop using Tri-Luma and get help right away if you have any of the following symptoms of a serious allergic reaction.Breathing problems or wheezingRacing heartFever or general ill feelingSwollen lymph nodesSwelling of the face, lips, mouth, tongue, or throatTrouble swallowing or throat tightnessItching, skin rash, or pale red bumps on the skin called hivesNausea or vomitingDizziness, feeling lightheaded, or faintingStomach crampsJoint painDarkening of the Skin (Exogenous Ochronosis). Tri-Luma can cause a gradual blue-black darkening of the skin known as exogenous ochronosis. Stop using the product and tell your healthcare provider if you notice any darkening of the skin.Reduced Adrenal Function. Tri-Luma can pass through your skin and cause your body’s adrenal glands to stop making as much cortisol (the stress hormone). This is known as adrenal insufficiency. Adrenal insufficiency can get worse if your body is under stress because of fever, surgery, or trauma. Tell your healthcare provider if you have any of the following symptoms of adrenal insufficiency.Nausea and vomitingWeakness, tiredness, or lack of energyLow blood pressureCushing’s Syndrome. Tri-Luma can cause Cushing’s syndrome, a condition that happens when your body is exposed to too much cortisol (the stress hormone). Tell your healthcare provider if you notice any of the following symptoms.Rounded, rosy faceWeight gain, especially in the upper bodyThinning of skinAcnesUnusualy tiredness or weaknessDepressed mood or anxietyKidney stonesSleep problemsUnusual hair growthHigh Blood Sugar. Tri-Luma may increase your blood sugar levels. It may also cause your body to leak sugar into your urine (pee). Talk to your healthcare provider about how to maintain healthy blood sugar levels. Also tell them if you keep track of your blood sugar and notice unusual increases.Skin Reactions. Tri-Luma may cause skin reactions such as irritation, blistering, burning or swelling. While many of these reactions generally go away on their own, some of them may be more severe. Stop using Tri-Luma and tell your healthcare provider if you have any allergic rash or any other severe skin reactions, such as blistering, crusting, or severe burning.
overdose and misseddose
What should I do if I accidentally use too much Tri-Luma?If you or someone else has used too much Tri-Luma, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.What should I do if I miss a dose of Tri-Luma?If you miss your scheduled dose of Tri-Luma, apply it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and follow the original schedule. Do not apply Tri-Luma more often than prescribed.
warnings and Precautions
Who should not use Tri-Luma?Allergies to Ingredients. People who are allergic to any of the following should not use Tri-Luma.FluocinoloneHydroquinoneTretinoinTri-LumaAny of the ingredients in the specific product dispensedYour pharmacist can tell you all of the ingredients in Tri-Luma.What should I know about Tri-Luma before using it?Do not use Tri-Luma unless it has been prescribed to you by a healthcare provider. Use it as prescribed.Do not share Tri-Luma with other people, even if they have the same condition as you. It may harm them.Keep Tri-Luma out of the reach of children.While using Tri-Luma, avoid using skin products that can irritate your skin, such as medicated or abrasive soaps or cleansers, skin products with drying effects, and skin products that contain high amounts of alcohol or astringents. These products can increase the risk of developing severe skin reactions to Tri-Luma.Gently wash your face with a mild cleanser, rinse, and pat your face dry before applying Tri-Luma. When you apply Tri-Luma, include about half-inch of normal skin surrounding the area with melasma. Gently rub the cream uniformly into the skin.Tri-Luma can make your skin more susceptible to the harmful effects of sunlight. Use sunscreen (with SPF of 30 or higher) and wear a hat and clothes that cover your skin if you need to be in the sunlight. Tri-Luma can make your skin more sensitive to extreme weathers such as heat or cold. Your skin may be irritated more easily under these conditions while using Tri-Luma.If Tri-Luma causes dryness, you can apply a moisturizer to your face in the morning after washing.Do not apply Tri-Luma to your eyes, nose, corners of your mouth, or any open wounds. Such areas are more likely to be irritated by Tri-Luma. Also avoid applying Tri-Luma to your mouth or vagina. Doing so may increase your risk of developing serious side effects.Do not bandage, wrap, or otherwise seal the area where Tri-Luma is applied.Thoroughly wash your hands after each application.Stop using Tri-Luma once the skin condition is under control.What should I tell my healthcare provider before using Tri-Luma?Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Tri-Luma is right for you.In particular, make sure that you discuss any of the following.Sulfite Allergy. The risk of having a dangerous allergic reaction with Tri-Luma may be higher in people with sulfite allergy. Tell your healthcare provider if you are allergic to sulfites.Adrenal Gland Problems. Tri-Luma can cause adrenal insufficiency. Tell your healthcare provider if you have any preexisting adrenal gland problems.Diabetes. Tri-Luma can increase your blood sugar. Tell your healthcare provider if you have diabetes.Hormonal Birth Control. Tell your healthcare provider if you are using a hormonal birth control method. Hormonal birth control may worsen your melasma.Pregnancy. Tri-Luma may cause harm to an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Tell your healthcare provider right away if you become pregnant.Breastfeeding. It is not known if Tri-Luma passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Tri-Luma while breastfeeding. If you use Tri-Luma while breastfeeding, avoid skin-to-skin contact between your baby and the skin areas treated with Tri-Luma.How can I get more information about Tri-Luma?For more information about Tri-Luma, you can visit the manufacturer’s website at www.triluma.com or call them at 866-735-4137.
about
Tri-Luma is used to treat a condition called melasma, which is where colored areas appear on the face. Tri-Luma contains three medicines. Fluocinolone and hydroquinone help reduce skin darkening while tretinoin helps hydroquinone work. The most common side effects include skin reactions, such as redness, peeling, burning, dryness, itching, and acne.