uses
What is Synarel used for?Synarel (nafarelin) is commonly used to treat central precocious puberty and endometriosis.Synarel may also be used for other conditions as determined by your health care provider.How does Synarel work (mechanism of action)?Synarel works by blocking certain hormones in the body. Specifically, it tells the brain to ignore gonadotropin-releasing hormone (GnRH), which is responsible for telling the body to start puberty. It also temporarily reduces estrogen levels, which may relieve endometriosis symptoms. How is Synarel supplied (dosage forms)?Brands and other namesSynarelDosage forms and strengths2 mg/mL nasal solution (nasal spray)How should I store Synarel?Synarel should be stored upright at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.
how to use
nasal spray
drug interactions
Does Synarel interact with foods or drinks?There are no known interactions between Synarel and foods or drinks.It is unknown if drinking alcohol will affect Synarel.Does Synarel interact with other medicines (drug interactions)?Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.In particular, make sure that you discuss if you are using any of the following before using Synarel.A birth control pill, patch, vaginal ring, implant, injection, or intrauterine device (IUD)Bupropion (Aplenzin, Wellbutrin SR, Wellbutrin XL, and others), which is a medicine used to treat depression or help quit smokingA selective serotonin reuptake inhibitor (SSRI), such as fluoxetine, paroxetine, or sertraline, which is a medicine commonly used for anxiety and depressionThis may not be a complete list of medicines that can interact with Synarel. Always check with your health care provider.
side effects
What are the most common side effects of Synarel?The most common side effects of Synarel are listed below. Tell your health care provider if you have any of these side effects that bother you.AcneChanges in breast sizeMenstrual (period) bleedingMood changesIncrease in pubic hairBody odorItchy, flaky rash on the skin or scalpThere may be other side effects of Synarel that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.What are the serious side effects of Synarel?While less common, the most serious side effects of Synarel are described below, along with what to do if they happen.Severe Allergic Reactions. Synarel may cause allergic reactions, which can be serious. Stop using Synarel and get help right away if you have any of the following symptoms of a serious allergic reaction.Breathing problems or wheezingRacing heartFever or general ill feelingSwollen lymph nodesSwelling of the face, lips, mouth, tongue, or throatTrouble swallowing or throat tightnessItching, skin rash, or pale red bumps on the skin called hivesNausea or vomitingDizziness, feeling lightheaded, or faintingStomach crampsJoint painMental Health Problems. Synarel may cause mood swings or depression to occur or worsen. If you have any thoughts of harming yourself, call 911 or call or text 988, the Suicide & Crisis Lifeline. Call your health care provider right away if you have any of the following symptoms.CryingIrritabilityRestlessness (impatience)AngerAggressive behaviorSeizures. Some people who have used Synarel have reported having seizures. There are many different types of seizures, and some of them are not easy to recognize. Stop using Synarel and call your health care provider if you have any of the following signs that a seizure is happening or could happen.Muscle twitching, jerking, spasms, tremors, or other uncontrolled movementsStiffening of your arms and legsFeeling anxious, nervous, confused, or a sense of dreadFeeling dizzy or lightheadedFalling or losing consciousnessIncreased Pressure Around the Brain. Synarel can increase the pressure around the brain, a serious condition called pseudotumor cerebri (or increased intracranial pressure). Stop using Synarel and call your health care provider right away if you have any of the following symptoms.DizzinessNausea and vomitingSevere headacheVision changes
overdose and misseddose
What should I do if I accidentally use too much Synarel?If you or someone else has used too much Synarel, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.What should I do if I miss a dose of Synarel?If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.
warnings and Precautions
Who should not use Synarel?Allergies to Ingredients. People who are allergic to any of the following should not use Synarel.NafarelinSynarelAny other GnRH agonistsAny of the ingredients in the specific product dispensedYour pharmacist can tell you all of the ingredients in Synarel.Pregnancy. Do not use Synarel if you are pregnant. If you become pregnant, contact your health care provider right away. See the Pregnancy section for more details.Breastfeeding. Do not use Synarel if you are breastfeeding. See the Breastfeeding section for more details.Vaginal Bleeding. Do not use Synarel if you have vaginal bleeding that has not received a diagnosis. If you do have a diagnosis with vaginal bleeding, talk with your health care provider to see if Synarel is safe for you. What should I know about Synarel before using it?Do not use Synarel unless it has been prescribed to you by a health care provider. Use it as prescribed.Do not share Synarel with other people, even if they have the same condition as you. It may harm them.Keep Synarel out of the reach of young children.In the first few weeks of treatment, Synarel can cause some hormones to have higher levels. The hormone levels should go back down within two months of starting treatment, but during this time, you may experience irregular vaginal spotting or bleeding. Call your health care provider if this lasts for longer than two months.Synarel can alter test results in pituitary-gonadotropic and hormone function tests while you are using the medicine and even after your last dose. Tell any health care provider you are seeing that you are using Synarel.Keep all appointments to see your health care provider. They will do regular exams and blood tests to ensure that Synarel is safe for you to take. They will also show you have to use the nasal spray correctly. Make sure to use Synarel exactly as they tell you.It is important to try to avoid sneezing while using Synarel or right after to make sure the dose can get absorbed into the body. What should I tell my health care provider before using Synarel?Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Synarel is right for you.In particular, make sure that you discuss any of the following.Current and Past Health Conditions. Tell your health care provider if you have any of the following.History of mental health problemsHistory of seizures or epilepsyHistory of brain problems or tumorsAlcohol usePrior or current smokingFamily history of osteoporosisVaginal bleedingOther Medicines and Supplements. Synarel may interact with other medicines and supplements. Before using Synarel, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.Ovarian Cysts. People being treated with Synarel for endometriosis have had ovarian cysts occur in the first two months of using Synarel. Talk with your health care provider if you have a history of problems with ovarian cysts.Pregnancy. Synarel may cause harm to a fetus. Do not use Synarel while pregnant. You should use a nonhormonal birth control (such as condoms) while using Synarel. Tell your health care provider if you are pregnant or plan to become pregnant. If you become pregnant, contact your health care provider right away. Breastfeeding. It is not known if Synarel passes into breast milk. Do not use Synarel while breastfeeding. Tell your health care provider if you are breastfeeding or plan to breastfeed. How can I get more information about Synarel?For more information about Synarel, you can visit the drugmaker’s website at www.pfizermedicalinformation.com/patient/synarel/medguide or call them at 800-438-1985.
about
Synarel is commonly used to treat early puberty and endometriosis. Common side effects include acne, changes in breast size, and menstrual (period) bleeding. Call your health care provider right away if you have depression, seizures, or problems with your vision. Synarel is a nasal spray.