uses
What is cisplatin used for?Cisplatin is commonly used to treat certain cancers including, ovarian cancer, testicular cancer, and bladder cancer.Cisplatin may also be used for other conditions as determined by your health care provider.How does cisplatin work (mechanism of action)?Cisplatin is a type of medicine known as chemotherapy. Cisplatin is an alkylating agent. It damages DNA, which prevents the ability of cancer cells to multiply. How is cisplatin supplied (dosage forms)?Brands and other namesPlatinolPlatinol-AQDosage forms and strengthsCisplatin is available in an injectable form that is given by a health care provider.How should I store cisplatin?Cisplatin is usually given by a health care provider in a hospital or clinic. You will not store it at home.
how to use
liquid that is injected into a blood vessel
drug interactions
Does cisplatin interact with foods or drinks?There are no known interactions between cisplatin and foods or drinks.It is unknown if drinking alcohol will affect cisplatin, but heavy drinking can slow your immune response and make it harder for your body to fight cancer.Does cisplatin interact with other medicines (drug interactions)?Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.In particular, make sure that you discuss if you are using any of the following before using cisplatin.An aminoglycoside antibiotic, such as amikacin or gentamicin, which is a medicine given by injection to treat infectionsA nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen, naproxen, and others, which is in many prescription and OTC products for pain, swelling, and feverThis may not be a complete list of medicines that can interact with cisplatin. Always check with your health care provider.
side effects
What are the most common side effects of cisplatin?The most common side effects of cisplatin are listed below. Tell your health care provider if you have any of these side effects that bother you.Kidney damage (see below)Nerve problems (see below)Nausea and vomiting (see below)Blood disorders (see below)Hearing problems (see below)Hair lossThere may be other side effects of cisplatin that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.What are the serious side effects of cisplatin?While less common, the most serious side effects of cisplatin are described below, along with what to do if they happen.Severe Allergic Reactions. Cisplatin may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.Breathing problems or wheezingRacing heartFever or general ill feelingSwollen lymph nodesSwelling of the face, lips, mouth, tongue, or throatTrouble swallowing or throat tightnessItching, skin rash, or pale red bumps on the skin called hivesNausea or vomitingDizziness, feeling lightheaded, or faintingStomach crampsJoint painKidney Damage. Kidney damage can happen when using cisplatin. You need to drink enough water while you are using this medicine. Do not get dehydrated. Call your health care provider right away if you have any of the following symptoms of kidney damage. Reduced need to peeSwelling in your feet, ankles, or legsWeakness or unusual tirednessDifficulty catching your breath or chest pain/pressureConfusionNauseaSeizuresNerve Problems. Nerves are the fibers that carry sensations from your body to the brain. Damage to these nerves, called peripheral neuropathy, can happen in people who are using cisplatin. Tell your health care provider if you get pain, burning, tingling, numbness, or weakness in your arms, hands, legs, or feet.Nausea and Vomiting. Cisplatin commonly causes nausea and vomiting, but these can be persistent or severe. If you are given medicine to prevent or treat stomach problems, take it exactly as your health care provider tells you. Tell your health care provider right away if you cannot keep any liquid down because of ongoing or severe nausea or vomiting.Blood Disorders. Cisplatin can cause blood disorders, such as low neutrophil levels (neutropenia), low red blood cell levels (anemia), low platelet levels (thrombocytopenia), and low white blood cell levels (leukopenia). Keep all appointments for blood work, so your health care provider can monitor your blood cell counts. Get help right away if you have any of the following symptoms of blood disorders.Fever or chillsSore throatShortness of breathPale or yellowish skinEasy bruising or bleedingFrequent infectionUnusual weakness or tirednessDizziness, lightheadedness, or feeling like you are about to pass outHeadacheFast or abnormal heartbeatHearing Problems. Cisplatin may be associated with hearing loss, which is also called ototoxicity. Tell your health care provider right away if you have hearing loss or if you hear a ringing or roaring sound in your ears.Eye Problems. Cisplatin can cause eye problems, such as swelling of your optic nerve (optic neuritis and papilledema), and cortical blindness. Tell your doctor right away if you have blurred vision or see colors differently. Cancer. Cisplatin can cause a new cancer called acute leukemia to develop. Tell your health care provider about any new symptoms that you may get.Tissue Damage. Cisplatin is given as an infusion into a vein. If the medicine does not go into your vein, it could damage nearby tissue. Tell your health care provider right away if you have pain, swelling, warmth, or skin color changes where the medicine is being or was given.
overdose and misseddose
What should I do if I accidentally use too much cisplatin?If you or someone else has used too much cisplatin, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.What should I do if I miss a dose of cisplatin?Cisplatin is usually given by a health care provider in a hospital. Your health care provider will make sure you are receiving cisplatin as scheduled.If you miss an appointment to get your cisplatin dose, call to make another appointment as soon as possible.Â
warnings and Precautions
Who should not use cisplatin?Allergies to Ingredients. People who are allergic to any of the following should not use cisplatin.CisplatinPlatinolPlatinol-AQAny of the ingredients in the specific product dispensedYour pharmacist can tell you all of the ingredients in the specific cisplatin products they stock.What should I know about cisplatin before using it?Cisplatin is usually given by a health care provider in a hospital or clinic. It is important to drink plenty of water and stay hydrated while using cisplatin to help to prevent kidney problems. Your health care provider may also tell you to drink electrolyte replacements before or after your cisplatin dose.Your health care provider will monitor your body’s response to cisplatin with blood tests. It is important to keep all appointments, so your health care provider can make sure it is safe for you to start and continue to use cisplatin. If you are able to get your partner pregnant, use effective birth control while using cisplatin and for 11 months after your last dose.Cisplatin may make it hard for you to get pregnant or get your partner pregnant. Infertility may be permanent. If you may want to have a child someday, talk to your health care provider.Hearing problems may be more severe in children who are younger than 5 years. Get a hearing evaluation if you are asked to have one done. People who are 65 years of age or older can be at greater risk of some side effects from cisplatin. Talk to your health care provider about your risks if you are in this age group.What should I tell my health care provider before using cisplatin?Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if cisplatin is right for you.In particular, make sure that you discuss any of the following.Current and Past Health Conditions. Tell your health care provider if you have any of the following.Kidney problemsHearing problemsAn infectionEye problemsOther Medicines and Supplements. Cisplatin may interact with other medicines and supplements. Before using cisplatin, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.Pregnancy. Cisplatin may cause harm to an unborn baby. Your health care provider will ensure you are not pregnant before you start using cisplatin. If you can become pregnant, use effective birth control while using cisplatin and for 14 months after your last dose. Tell your health care provider right away if you are pregnant or plan to become pregnant.Breastfeeding. Do not breastfeed while using cisplatin. Cisplatin passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.
about
Cisplatin is used to treat certain types of cancer. Common side effects include nausea and vomiting. Tell your health care provider right away if you have severe or persistent nausea or vomiting. Also, tell your health care provider right away if you get unusual bleeding, vision changes, hearing problems, or symptoms of an infection, such as a fever.