HOW DO FGFR INHIBITORS WORK?
Fibroblast growth factor receptor (FGFR) inhibitors are drugs used for treating cancer that originates in the skin or in tissues that line or cover internal organs (carcinoma).
FGFR is a receptor essential for the growth, differentiation, and maturation of a tumor cell. FGFR inhibitors bind to FGFRs and prevent their activity, thereby stopping tumor cell growth. As a result, the tumor cells fail to survive, leading to tumor cell death.
HOW ARE FGFR INHIBITORS USED?
FGFR inhibitors are used for the treatment of:
- Cholangiocarcinoma (cancer formed in the bile ducts)
- Urothelial carcinoma (cancer formed in the lining of the urinary tract)
WHAT ARE SIDE EFFECTS OF FGFR INHIBITORS?
The side effects of FGFR inhibitors may include:
- Hair fall
- Diarrhea
- Fatigue
- Low hemoglobin level
- Decreased white blood cell count
- Increased cholesterol
- Nausea
- Decreased electrolytes
- Vomiting
- Constipation
- Cough
- Headache
- Anemia
- Decreased weight
- Shortness of breath
- Abdominal pain
- Dry skin
- Back pain
- Urinary tract infection
- Pain in the legs
- Dry eyes
- Impaired sense of taste
The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.
WHAT ARE NAMES OF FGFR INHIBITORS?
Generic and brand names of FGFR inhibitors include:
- Balversa
- Erdafitinib
- Infigratinib
- Pemazyre
- Pemigatinib
