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Prozac Drug and Medication User Reviews on RxList

Prozac

USER REVIEWS

Comment from: Tominator 65-74 Transgender 6 months to less than 1 year Caregiver Published: October 02

Oct. 2025: Fluoxetine (Prozac) worked so well for me. At first. After a blissful and normal 9-month period, it abruptly stopped working. I took a long break from it and then tried again to see if a long vacation away from Prozac would bring back the same excellent results. No luck. After another year away from Prozac, I tried once more. Nothing. I gave up. My Dr will give me a "cheek swab" next. This is a fairly new procedure in 2025 where a sample is taken from inside your cheek area. The sample is then analyzed to find out what kind of medications might work for me better. Wish me luck.

Comment from: Lyndsey 19-24 Female Caregiver Published: February 07

10mg did wonders for my anxiety and depression, but when it got increased to 20mg, everything went downhill. I found out I had bipolar disorder from this medication, as it put me in a manic episode and attempted suicide. Please be careful and take with some kind of mood stabilizer with the medication if you have the condition.

Comment from: Rover.7 Transgender 6 months to less than 1 year Caregiver Published: September 23

I have major depressive disorder and I started taking this in April. I only took 10 MG, which is the lowest dose. I was originally put on birth control to help regulate my menstrual cycles and things were going good until they started me on Prozac. The very first day (First dose), like 2 hours later, I started having menstrual bleeding. It was totally random and I was not due to get my period at all. This random bleeding pattern continued for months and months, and my doctor’s never once mentioned that Prozac can screw with menstrual cycles. Well, since I initially blamed the birth control I was on, I just decided to get off of it because I assumed that would be the only thing causing that to happen. I was totally wrong. I’ve been off the birth control for over 3 months now and I’m still having random bleeding. It’s definitely the Prozac, my doctor has agreed to taper me off it starting tomorrow. Another huge concern is that I’ve gained over 10 pounds. I’m down to eating one tiny meal a day and I also exercise daily, yet somehow I manage to gain weight no matter what.

Comment from: Jack 35-44 Transgender less than 1 month Caregiver Published: September 14

I have depression i started prozac 4 weeks ago Today i feel wonderful i feel happy and satisfied thank you for creating this medicine

Comment from: Crystal Transgender less than 1 month Caregiver Published: September 03

I’ve been on this product for a week and half. I’m trying to do the full 2 weeks suggested by my dr. I feel so sick and can’t eat. My thoughts are to many and terrible. I’m confused and even more depressed. I’m so tired I just want to sleep. I wake up shaking and feel like the world is after me. Before I started taking it, I was suffering from depression, but this is a whole new ballgame I will honor the two weeks hopefully I start feeling better. There is nothing about Side effects like mine perhaps it is just me.

Comment from: Cynthia 25-34 Transgender 2 to less than 5 years Caregiver Published: September 02

Fluoxitine has helped me so much with my anxiety and depression. I have not had no side effects and has been the best one I've taken so far.

Comment from: longtimeuser 45-54 Transgender 10 years or more Caregiver Published: July 16

I've been on and off Prozac/Fluoxetine for 20 years. It does work for me. It makes me feel more optimistic and resilient, and with less social anxiety. I am most often on a 20 mg a day regimen. Sometimes I stop taking it for months, then start again when I feel I need to. I did have a 80 mg stint a long time ago when my work situation seems to have demanded it. I don't regret it, but I realize that such high dose did make me feel somewhat numb and I have never exceeded 40 mg since then. Delayed orgasm is an annoying but manageable side effect. Overall I am satisfied and believe it helps me live a more productive and content life.

Comment from: Jay 25-34 Transgender 1 to 6 months Caregiver Published: May 09

I started taking nuzak 20 mg 2 months ago cos I had depression,fear and anxiety and I just recently gave birth so I would constantly think I was going to die or fall and die if I’m walking so I became depressed and didn’t even want to go out anywhere if I did go out I would have panick attacks and feel weak then my doctor prescribed this then I first got worse before I got better the side effects were crazy cos it made me have suicidal thoughts at some point . Fast forward now I’m on 40mg and living the life I used to live no fear and no panic attacks and I meditate a lot with bible verses and even joined a Bible study and it’s working wonders I don’t feel like I will die anymore.i hope someone will read this and get themselves a Bible too cos it helped me to fight this

Comment from: Just done with this 55-64 Transgender 1 to 6 months Caregiver Published: May 02

This drug is horrible. First few days were good and I noticed my mood improved but as time went on I started feeling like a zombie, completely detached. Everything was flat. It took away any interest I had in anything and I started having trouble just getting out of bed. I felt dead inside. I never had that problem before. I also had intense dreams that often woke me up in a panic. I struggled with it for almost 3 months as I was told things would get better. Things just got worse and worse. It set my recovery back so badly. So i got off it, tapering for a couple of weeks, per my doctors recommendation. From everything I read, there wasn't supposed to be much in the way of withdrawal symptoms because of its long half life. Hah! I experienced fatigue, body aches, intense food cravings, headaches, weird thoughts and worsening of anxiety. Depression, anxiety and panic attacks are much easier to handle than the effects of this medication. On a scale of 1 to 10, I'd give it a -100

Comment from: Fortyeight 45-54 Transgender 1 to less than 2 years Caregiver Published: April 07

Prozac helped my anxiety and depression and really improved my overall mood. It made a big difference

Comment from: Anonymous 35-44 Transgender 1 to 6 months Caregiver Published: February 08

I feel like this medicine is making me feel worse, paranoid, racing thoughts not so much, memories an thoughts from years ago that I've not really had before! 10 mg An there is also 20 mg I'm having dark thoughts An also I changed from Lexapro to Prozac in Nov An it's been a real roller coaster ride!! Suggestions Advice (Be kind please)

Comment from: eventually 13-18 Transgender 1 to 6 months Caregiver Published: January 16

Prozac is good in terms of getting rid of anxiety and some parts of depression. Other than that, it is a horrible drug that has even worse side effects. The reason I had to take this is because of horrible irrepressible thoughts triggered by a traumatic event that my parents put me through. I will start off with the fact that after 3 weeks of taking this medication (for me), I felt like I was disassociating from reality at a rapid rate. I felt like a zombie that could no longer feel emotion or anything of that nature. I have been off of Prozac for about two months now and I cannot feel emotions to the effect that I could before I took it. Also, Prozac has completely and utterly obliterated my sex drive, and given me erectile dysfunction (I know.. amazing right!?!?) It has also impacted my confidence and as an aspiring model, that's definitely not something I needed. I don't get excited for anything anymore, nothing makes me happy anymore, I can barely cry, and I want to kill myself more than ever :) Please, for me, never torture yourself by taking this medicine.

Comment from: Nicole 35-44 Transgender 1 to 6 months Caregiver Published: December 30

I have been taking Prozac for 3 months. My anxiety is way worse with paranoia.

Comment from: Lstephens Transgender 5 to less than 10 years Caregiver Published: December 20

This medication saved me from intense anxiety and panic attacks. Occasionally i will have to adjust dosage at stressful times in my life, raising the dosage. I have noticed on higher dosages I feel alot more fatigue and start to feel a little numb. But this is manageable for me when needed over having the anxiety and panic attacks. I’ve been on it for about 5 years now. I still have some anxiety which i believe is just me. But it is manageable now instead of debilitating. I still feel like me on this medication. If anything i’m happier. I’ve never been on any other anxiety / Depression medication. This is the one that works best in my family.

Comment from: Ian 75 or over Transgender less than 1 month Caregiver Published: November 12

This is the worst drug I have ever taken in my 82 years of life. Even after stoping the use of the drug for 14 days I am having problems of a slow heart beat. I HATE THIS DRUG. It is totally without virtue. I used the drug for 4 weeks.

Comment from: user1998 19-24 Transgender less than 1 month Caregiver Published: November 09

I was having occasional chest pain/tightness from anxiety and had a few panic attacks so I tried taking this drug. I was on it for about three weeks, first few days felt nothing, after that my anxiety was worse than it has ever been along with other symptoms such as weird tastes in my mouth, rapid heart rate, and just overall feeling crappy. Out of the three weeks I was on it, I felt good (having no anxiety or anxiety-related symptoms) for 3 days. Stopped taking today so I'm hoping I can go back to feeling normal.

Comment from: Oliver 13-18 Transgender 2 to less than 5 years Caregiver Published: September 02

I took this medication mainly for my depression, but it really didn't do anything for that. I'm now on a second anti-depressent which has actually helped. I stayed on fluoxtine though, because it really helped my anxiety. I'm so much more confident now, and don't get panic attacks just trying to talk to somebody new. The worst part of this medication was the NAUSEA. It was BAD. I could barely eat for months, and even threw up a couple times. It's gone now but that was a really rough couple of months.

Comment from: K 13-18 Transgender 2 to less than 5 years Caregiver Published: August 02

Made me feel worse after a while. It did help at first

Comment from: DOL Transgender 6 months to less than 1 year Caregiver Published: July 05

I have been taking Prozac 20 mg for about 6 months, and it has been helping me feel better. I had so many intrusive thoughts and Panic attacks related to Marijuana. I started with Abilify and had many side affect from sleeping 12 hours a day and wanting to sleep all day. I did gain a couple of pounds since taking Prozac and I had tremours on my hands for a few weeks in the beginning but those are gone. Knowing I had some form of Anxiety my whole life refused to take any medication and Marijuana triggered my intrusive thoughts and Panic attacks.

Comment from: 45-54 Transgender Caregiver Published: July 02

I’ve had terrible PMS for years but was reluctant to take another antidepressant because I had bad luck with Paxil - it increased my intrusive thoughts. However finally my irritability and sadness the two weeks leading up to my period every month were getting unbearable. I’ve only been on this for two weeks but already have noticed a big improvement.

SLIDESHOW

Learn to Spot Depression: Symptoms, Warning Signs, Medication See Slideshow
References
Medical Editor: John P. Cunha, DO, FACOEP