Fosinopril

Fosinopril is a prescription medication used to treat the symptoms of high blood pressure (hypertension) and congestive heart failure. 

• Fosinopril is available under the following different brand names: Monopril

Common side effects of Fosinopril include:

• Cough,
• Runny or stuffy nose,
• Muscle or joint pain,
• Dizziness,
• Headache,
• Tired feeling,
• Nausea,
• Vomiting,
• Diarrhea, and
• Mild skin itching or rash

Serious side effects of Fosinopril include:

• Hives,
• Difficulty breathing,
• Swelling of the face, lips, tongue, or throat,
• Severe stomach pain,
• Lightheadedness,
• Sudden weakness,
• ill feeling,
• Fever,
• Chills,
• Sore throat,
• Painful mouth sores,
• Cough,
• Little or no urination,
• Nausea,
• Slow or unusual heart rate,
• Weakness, and
• Loss of movement

Rare side effects of Fosinopril include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Tablets

• 10 mg
• 20 mg
• 40 mg

Hypertension

Adult dosage

• 10 mg orally once a day initially, no more than 40 mg/day

Pediatric dosage

• Children below 50 kg: Limited data suggest 0.1-0.6 mg/kg orally once a day 
• Children above 50 kg: As adults; 5-10 mg orally once a day initially, not to exceed 40 mg/day

Congestive Heart Failure

Adult dosage

• 5-10 mg orally once a day initially, no more than 40 mg/day

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Fosinopril has severe interactions with the following drugs
  • Aliskiren
  • Protein a column
  • Sacubitril/valsartan
• Fosinopril has serious interactions with at least 37 other drugs.
• Fosinopril has moderate interactions with at least 108 other drugs.
• Fosinopril has minor interactions with at least 28 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity
• History of hereditary or angioedema associated with previous ACE inhibitor treatment
• Coadministration of neprilysin inhibitors (. g, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of switching to or from sacubitril/valsartan
• Bilateral renal artery stenosis
• Do not coadminister aliskiren in patients with diabetes mellitus or with renal impairment (. e., GFR below 60 mL/min/1.73 m²)

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Fosinopril?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Fosinopril?”

Cautions

• Renal impairment, hepatic impairment, volume depletion, electrolyte abnormalities
• Risk of hyperkalemia, especially with renal impairment, DM, or those taking concomitant K+-elevating drugs
• Dual blockade renin-angiotensin system with ARBs, ACE inhibitors, or aliskiren associated with increased risk for hypotension, hyperkalemia, and renal function changes (including acute renal failure) compared to monotherapy
• ACE inhibition also causes increased bradykinin levels which putatively mediates angioedema
• Coadministration with mTOR inhibitors (.g, temsirolimus) may increase the risk for angioedema
• Discontinue STAT if pregnant (see Contraindications and Black Box Warnings)
• Less effective in Blacks
• Renal impairment may occur
• Neutropenia/agranulocytosis reported
• Cough may occur within the first few months
• Cholestatic jaundice may occur
• Use caution in severe aortic stenosis
• Excessive hypotension if concomitant diuretics, hypovolemia, hyponatremia

Pregnancy and Lactation

• Use in LIFE-THREATENING emergencies when no safer drug is available.
• Discontinue as soon as pregnancies are detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with a fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
• Lactation
  • Excreted in breast milk; not recommended