Gadobenate dimeglumine

Gadobenate dimeglumine is a contrast agent used to help diagnose certain disorders of the brain and spine (central nervous system). This medication is also used to diagnose atherosclerosis (clogged arteries).

• Gadobenatete dimeglumine is available under various brand names: Multihance

Common side effects of Gadobenate dimeglumine include:

• headache.
• nausea; or
• unusual or unpleasant taste in the mouth.

Serious side effects of Gadobenate dimeglumine include:

• hives. 
• difficult breathing. 
• swelling of the face, lips, tongue, or throat.
• burning, itching, swelling, scaling, and tightening or hardening of the skin.
• muscle weakness.
• joint stiffness in the arms, hands, legs, or feet.
• deep bone pain in the ribs or the hips.
• trouble moving; or
• skin redness or discoloration.
• kidney problems--little or no urinating; painful or difficult urination; swelling in the feet or ankles; feeling tired or short of breath.
• a seizure (convulsions).
• pounding heartbeats or fluttering in the chest.
• breathing problems; or
• pain, burning, swelling, blistering, or skin changes at the injection site.

Rare side effects of Gadobenate dimeglumine include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Severe eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Severe heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Intravenous solution

• 529 mg/Ml

CNS imaging:

Adult dosage

• IV: 0.1 mmol/kg (0.2 mL/kg).

Pediatric dosage

• Infants and Children below 2 years of age:
• IV: 0.1 to 0.2 mL/kg (0.05 to 0.1 mmol/kg); may begin imaging immediately after administration.

Children above 2 years and Adolescents:

• IV: 0.2 mL/kg (0.1 mmol/kg); may begin imaging immediately after administration.

Renal and aorto-iliofemoral vasculature imaging:

Adult dosage

• IV: 0.1 mmol/kg (0.2 mL/kg); calculate scan delay with test bolus (1 to 2 mL) or with automatic detection technique.

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

• Gadobenate dimeglumine has no noted severe interactions with any other drugs.
• Gadobenate dimeglumine has no noted serious interactions with any other drugs.
• Gadobenate dimeglumine has no noted moderate interactions with any other drugs.
• Gadobenate dimeglumine has no noted minor interactions with any other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to gadobenate dimeglumine
• Kidney disease
• Dialysis

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Gadobenate dimeglumine?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Gadobenate dimeglumine?”

Cautions

• Gadobenate dimeglumine can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.
• Gadobenate dimeglumine can stay in your body for months or years after you receive this medicine. It is not known whether this could cause any health problems in people whose kidneys work properly. Tell your doctor if you have had repeated scans with a contrast agent, and provide the date of your last scan.

Pregnancy and Lactation

• It is not known whether this Gadobenate dimeglumine will harm an unborn baby. Tell your doctor if you are pregnant.

Lactation

• It may not be safe to breastfeed while using this gadobenate dimeglumine. Ask your doctor about any risks.