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Gallium Nitrate: Side Effects, Uses, Dosage, Interactions, Warnings

Gallium Nitrate

What Is Gallium Nitrate Used For and How Does it Work?

Gallium nitrate was used to treat cancer-related hypercalcemia. The product was discontinued by the manufacturer in 2012.

Gallium nitrate is available under the following different brand names: Ganite.

What Are the Dosages of Gallium Nitrate?

Dosages of Gallium Nitrate:

Adult and Pediatric Dosage Forms and Strengths

Injectable Solution

  • 25mg/mL (product discontinued)

Dosage Considerations – Should be Given as Follows:

Cancer-related Hypercalcemia

  • Discontinued by the manufacturer (4/4/2012)
  • Premedicate to prevent hypersensitivity reactions (e.g., dexamethasone, diphenhydramine, H2 blockers)
  • 100-200 mg/m2 intravenously (IV) over 24 hours for 5 days; may shorten treatment if calcium levels return to normal in < days

Renal Impairment

  • Moderate renal impairment: Dose adjustment not provided by manufacturer's labeling; monitor renal status
  • Severe renal impairment: Contraindicated

Not recommended for use in pediatric patients.

What Are Side Effects Associated with Using Gallium Nitrate?

Side effects of Gallium Nitrate may include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Gallium Nitrate?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Gallium nitrate has no listed severe interactions with other drugs.
  • Gallium nitrate has no listed serious interactions with other drugs.
  • Gallium nitrate has no listed moderate interactions with other drugs.
  • Gallium nitrate has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Gallium Nitrate?

Warnings

  • This medication contains Gallium Nitrate. Do not take Ganite if you are allergic to gallium nitrate or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Black Box Warnings

  • Concurrent use of gallium nitrate with other potentially nephrotoxic drugs (eg, aminoglycosides, amphotericin B) may increase the risk for developing severe renal insufficiency in patients with cancer-related hypercalcemia. If the use of a potentially nephrotoxic drug is indicated during gallium nitrate therapy, gallium nitrate administration should be stopped and hydration continued for several days after administration of the potentially nephrotoxic drug.
  • Serum creatinine and urine output should be closely monitored during and after therapy. Discontinue therapy if the serum creatinine level exceeds 2.5 mg/dL.

Contraindications

  • Severe renal impairment (serum creatinine greater than 2.5 mg/dL)

Effects of Drug Abuse

  • No information is available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Gallium Nitrate?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Gallium Nitrate?"

Cautions

  • Therapy may result in mild-to-moderate or asymptomatic hypocalcemia (discontinuation of therapy may be necessary)
  • Use caution in cardiovascular disease
  • Discontinue therapy during treatment with nephrotoxic drugs

Pregnancy and Lactation

  • Use gallium nitrate with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done. It is unknown if gallium nitrate passes into breast milk. Gallium nitrate is not recommended for use while breastfeeding.
References
https://reference.medscape.com/drug/ganite-gallium-nitrate-342245