Ganirelix

Ganirelix is a prescription medication used for the treatment of female infertility.

• Ganirelix is available under the following different brand names: Antagon, Orgalutran

Common side effects of Ganirelix include:

• injection site reactions (pain, redness, or irritation)
• headache
• mild nausea
• stomach pain
• tiredness
• pelvic pain (like menstrual cramps) or vaginal bleeding

Serious side effects of Ganirelix include:

• hives
• difficulty breathing
• swelling of the face, lips, tongue, or throat
• stomach pain
• bloating
• nausea
• vomiting
• diarrhea
• rapid weight gain, especially in the face and midsection
• little or no urination
• pain while breathing, rapid heart rate, and shortness of breath (especially when lying down)

Rare side effects of Ganirelix include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Prefilled syringe

• 250 mcg/0.5 mL

Female infertility

Adult dosage

• 250 mcg SC once a day during the mid-to-late phase after initiating follicle-stimulating hormone (FSH) on day 2 or 3 of the cycle
• Continue treatment until the day of chorionic gonadotropin administration

Dosage Considerations – Should be Given as Follows:

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, healthcare provider, or pharmacist first.

• Ganirelix has no noted severe interactions with any other drugs.
• Ganirelix has no noted serious interactions with any other drugs.
• Ganirelix has no noted moderate interactions with any other drugs.
• Ganirelix has no noted minor interactions with any other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• Known or suspected pregnancy
• Hypersensitivity to Ganirelix, luteinizing hormone-releasing hormone (LHRH), or LHRH analogs

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Ganirelix?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Ganirelix?”

Cautions

• Exclude pregnancy before initiating therapy
• Packaging may contain latex products, which may cause allergic reactions in susceptible patients
• Use caution in women with signs and symptoms of active allergic conditions

Pregnancy and Lactation

• Contraindicated in pregnant women
• Lactation
  • Should not be used by lactating women
  • Unknown whether a drug is excreted in human milk
  • Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or any underlying maternal condition