Grape Seed Extract

Grape seed extract suggested uses include for atherosclerosis, attention deficit disorder, cancer (prevention), chronic venous insufficiency, collagen breakdown (prevention), dental caries (cavities) prevention, macular degeneration, peripheral vascular disease, poor night vision, retinopathy, varicose veins, and endometriosis.

Grape seed extract is effective in relieving symptoms of circulatory disorders.

One randomized controlled trial of grape seed extract indicates it is effective in reducing symptoms of endometriosis (Kohama, Journal of Reproductive Medicine).

Grape seed extract is not effective against signs of aging, and collagen destruction.

Grape seed extract is available under the following different brand and other names: activin, leucoanthocyanin, Muscat, muskat, pine bark extract, Pinus maritima, Pinus nigra, proanthodyn, pycnogenol, Vitis coignetiae, and Vitis vinifera.

Suggested Dosing

Chronic Venous Insufficiency

Extract procyanidin: 150-300 mg orally once/day

Tablets/Capsules: 75-300 mg/day for 3 weeks, THEN 40-80 mg/day OR

360 mg or 720 mg once daily (Antistax, Boehringer Ingelheim) orally once/day

Ocular Stress Reduction

Extract procyanidin: 200-300 mg orally once/day

Other Information

Endometriosis (based on randomized controlled trial): 30 mg orally twice daily

Dosage Considerations – Should be Given as Follows:

See “Suggested Dosing”

Side effects of grape seed extract include:

• Headache
• Itchy scalp
• Dizziness
• Nausea
• Potential for liver damage

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

• Grape seed extract has no known severe interactions with other drugs.
• Grape seed extract has no known serious interactions with other drugs.
• Grape seed extract has no known moderate interactions with other drugs.
• Grape seed extract has no known mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

This medication contains grape seed extract. Do not take activin, leucoanthocyanin, Muscat, muskat, pine bark extract, Pinus maritima, Pinus nigra, proanthodyn, pycnogenol, Vitis coignetiae, or Vitis vinifera if you are allergic to grape seed extract or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

None reported

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using Grape Seed Extract?"

Long-Term Effects

• See "What Are Side Effects Associated with Using Grape Seed Extract?"

Cautions

Concurrent sedative agents, diabetes mellitus, hyperlipidemia

Pregnancy and Lactation

There is no information available about use of grape seed extract during pregnancy or while breastfeeding. Consult your doctor.