HLA-Matched Platelets

HLA-matched platelets are used for patients that have thrombocytopenia and have demonstrated CCI values consistent with immune refractory thrombocytopenia on at least two occasions.

HLA-matched platelets are available under the following different brand names: N/A.

Dosages of HLA-Matched Platelets:

• There is no difference in dosing HLA-matched platelets compared to standard platelet dosing. Please see the platelet monograph for dosing information.

Dosage Considerations – Should be Given as Follows:

Thrombocytopenia

• There is no difference in dosing HLA-matched platelets compared to standard platelet dosing. Please see the platelet monograph for dosing information.

Other Indications and Uses

• HLA-matched platelets are indicated for patients that have thrombocytopenia and have demonstrated CCI values consistent with immune refractory thrombocytopenia on at least two occasions. Although antibodies against HLA Class I antigens are the most common cause of alloimmune refractory thrombocytopenia, antibodies against ABO, or less commonly platelet specific antigens may be involved.
• Patients with alloimmune thrombocytopenia due to HLA antibodies include multiparous women, recipients of multiple transfusions (particularly platelet or granulocyte transfusions), and recipients of organ transplants. Neonates may also experience transient thrombocytopenia and leukopenia due to passively acquired maternal HLA antibodies. Neonatal alloimmune thrombocytopenia (NAIT) is not usually as severe when due to HLA antibodies as compared to platelet-specific antibodies.
• HLA-matching requires typing the patient for HLA Class I antigens. Additional studies, including screening for HLA antibodies and other platelet serology assays, may be useful. Alternatively, platelet crossmatching may be performed to screen for platelets that might have improved post-transfusion increments.
• Strategies for providing platelets for alloimmune thrombocytopenia vary by institution and your blood bank physician should be consulted for assistance.

Side effects of HLA-matched platelets include:

• Hemolytic Transfusion Reactions
• Febrile Non-Hemolytic Reactions
• Allergic Reactions ranging from hives to anaphylaxis
• Septic Reactions
• Transfusion Related Acute Lung Injury (TRALI)
• Circulatory Overload
• Transfusion Associated Graft Versus Host Disease
• Post-transfusion Purpura

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• HLA-matched platelets have no listed severe interactions with other drugs.
• HLA-matched platelets have no listed serious interactions with other drugs.
• HLA-matched platelets have no listed moderate interactions with other drugs.
• HLA-matched platelets have no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

• This medication contains HLA-matched platelets. Do not take HLA-matched platelets if you are allergic to HLA-matched platelets or any ingredients contained in this drug.
• Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• HLA-matched platelets are not indicated in patients that have not demonstrated alloimmune refractoriness. Some institutions attempt to provide HLA-matched platelets to patients waiting for transplants to reduce HLA sensitization, however, this approach is not practical or possible for most institutions.

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using HLA-Matched Platelets?”

Long-Term Effects

• See "What Are Side Effects Associated with Using HLA-Matched Platelets?”

Cautions

• HLA-matched platelets should always be irradiated to prevent TA-GVHD. Ordering HLA-matched platelets may require a marked time delay of days to weeks or may not even be possible. Consult your blood bank physician and/or hematologist for recommendations in managing bleeding patients with alloimmune thrombocytopenia.
• HLA-matching does not guarantee expected platelet transfusion responses and it is not uncommon to see suboptimal platelet increment increases.
• Please see the platelet monograph for complete safety/caution information.

Pregnancy and Lactation

• Please see the platelet monograph for complete safety/caution information regarding the use of HLA-matched platelets during pregnancy and while breastfeeding.