How Do CNS Depressants Work?

Central nervous system (CNS) depressants are drugs that work by slowing brain activity and are beneficial in treating chronic sleep disorders (narcolepsy).

CNS depressants have a compound called gamma-hydroxybutyrate, which is also naturally present in the body and gets converted into gamma aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter that inhibits brain activity, inducing a calming effect and drowsiness essential for treating narcolepsy.

CNS depressants are mainly used to treat sleep disorders such as narcolepsy.

CNS depressants can cause the following side effects:

• Headache
• Nausea
• Vomiting
• Decreased weight 
• Dizziness
• Decreased appetite
• Parasomnia (a sleep disorder that causes abnormal behavior while sleeping)
• Diarrhea
• Hyperhidrosis (excessive sweating)
• Anxiety
• Fatigue
• Dry mouth
• Depressed mood
• Enuresis (bed-wetting)
• Irritability
• Paresthesia (burning or prickling sensation)
• Depression 
• Tremor
• Sleepiness
• Muscle spasms

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of CNS depressants include:

• Calcium/magnesium/potassium/sodium oxybates
• GHB (synonym)
• Oxybate sodium
• Sodium oxybate
• Xyrem
• Xywav