How Do Extravasation Antidotes Work?

Extravasation antidotes are drugs that reverse the effect of extravasation. Extravasation refers to the leakage of injected drugs from blood vessels causing damage to the surrounding tissues. Some of the common symptoms of extravasation include:

• Pain
• Stinging or burning sensation
• Swelling around the injection site

Extravasation antidotes improve the absorption of locally injected drugs and prevent their leakage into the surrounding tissue.

Extravasation antidotes are mainly used to treat extravasation. Some of their other uses include:

• Skin test
• Hypodermoclysis (subcutaneous fluid infusions)
• Urography (an examination used to evaluate the kidneys, ureters, and bladder)
• Pheochromocytoma (a small tumor of the adrenal glands)
• Hypertensive crisis (a severe increase in blood pressure that can lead to a stroke)

Extravasation antidotes may cause these side effects:

• Nasal congestion
• Diarrhea
• Injection site pain
• Chest pain
• Hypotension (low blood pressure)
• Myocardial infarction
• Headache
• Local irritation
• Disorientation
• Prolonged bleeding therapy
• Warmth

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of extravasation antidotes include:

• Amphadase
• Brethaire
• Brethine
• Bricanyl
• Hyaluronidase
• Hylenex Recombinant
• OraVerse
• Phentolamine
• Regitine
• Sodium thiosulfate
• Terbutaline
• Vitrase