How Do Factor XA Inhibitor Antidotes Work?

Factor XA inhibitor antidotes are drugs used for the reversal of anticoagulation or blood thinning. They work by binding to the clotting factor XA. Factor XA plays a critical role in blood clotting and prevents blood loss after an injury by sealing the wound.

Factor XA inhibitor antidotes exert their coagulant effect by binding and isolating factor XA inhibitors. Thus, they initiate coagulation and prevent blood loss.

Factor XA inhibitor antidotes are used for the reversal of anticoagulation in life-threatening or uncontrolled bleeding.

As factor XA inhibitor antidotes have a coagulant effect, they may have the following side effects:

• Deep vein thrombosis
• Ischemic stroke
• Acute myocardial infarction
• Pulmonary embolism
• Sudden death
• Acute respiratory failure
• Cardiac arrest
• Infusion-related reactions

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of factor XA inhibitor antidotes include:

• Andexanet alfa
• Andexxa
• Coagulation factor XA recombinant, inactivated-zhzo