Hydrochlorothiazide-Bisoprolol

Hydrochlorothiazide and Bisoprolol is a combination medication used for treating high blood pressure (hypertension). 

• Hydrochlorothiazide and Bisoprolol are available under various brand names: Ziac 

Common side effects of Hydrochlorothiazide and Bisoprolol include:

• dizziness, spinning sensation.
• feeling weak or tired.
• diarrhea, nausea, upset stomach.
• headache.
• cough, runny nose; or
• sleep problems (insomnia).

Serious side effects of Hydrochlorothiazide and Bisoprolol include:

• hives. 
• difficulty breathing. 
• swelling of the face, lips, tongue, or throat.
• chest pain.
• fast, slow, or uneven heartbeats.
• a light-headed feeling,
• blurred vision, tunnel vision, eye pain, or seeing halos around lights.
• shortness of breath (even with mild exertion), swelling, rapid weight gain.
• low potassium--leg cramps, constipation, irregular heartbeats, fluttering in the chest, extreme thirst, increased urination, numbness or tingling, muscle weakness, or limp feeling.
• liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
• low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or
• severe skin reaction--fever, sore throat, swelling in the face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Rare side effects of Hydrochlorothiazide and Bisoprolol include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Tablet

• 2.5 mg/6.25 mg
• 5 mg/6.25 mg
• 10 mg/6.25 mg

Hypertension

Adult dosage

• Initial: 2.5 mg/6.25 mg tablet orally every day
• Increase based on clinical response every 2 weeks
• To minimize dose-independent side effects, it is usually appropriate to begin combination therapy only after a patient has failed to achieve the desired effect with monotherapy
• Maximum: 20 mg bisoprolol /12.5 mg hydrochlorothiazide orally every day.

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Hydrochlorothiazide and Bisoprolol have severe interactions with no other drugs.
• Hydrochlorothiazide and Bisoprolol have serious interactions with at least 34 other drugs.
• Hydrochlorothiazide and Bisoprolol have moderate interactions with at least 248 other drugs.
• Hydrochlorothiazide and Bisoprolol have minor interactions with at least 164 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to hydrochlorothiazide and bisoprolol
• Severe or uncontrolled heart failure.
• Slow heartbeats that have caused you to faint.
• Aerious heart condition called "sick sinus syndrome" or "AV block" (2nd or 3rd degree); or
• If you are unable to urinate.

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Hydrochlorothiazide and Bisoprolol?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Hydrochlorothiazide and Bisoprolol?”

Cautions

• You should not use this medicine if you are unable to urinate. You should not use hydrochlorothiazide and bisoprolol if you have a serious heart condition such as "sick sinus syndrome" or "AV block," severe heart failure, or slow heartbeats that have caused you to faint.
• Hydrochlorothiazide and bisoprolol is not approved for use by anyone younger than 18 years old.
• Avoid drinking alcohol. It may increase your blood levels of bisoprolol.
• Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb hydrochlorothiazide and bisoprolol.
• Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Pregnancy and Lactation

• It is not known whether hydrochlorothiazide and bisoprolol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
• Lactation
  • Hydrochlorothiazide and bisoprolol can pass into breast milk and may harm a nursing baby. You should not breastfeed while using hydrochlorothiazide and bisoprolol.