Experience trauma to knee from fall after damage from osteoarthritis knees were very painful walking and bending was impossible. After I sections I could resume all gardening labors after a few days of rest . I have had 4 rounds of Synvisc.
I was mistakenly injected with Synvisc instead of Euflexxa and had a horrible, painful reaction. My knee swelled to the size of a bowling ball and the pain and discomfort was unrelenting. It is almost a year later and I still feel as though I have a metal blade in my knee if I kneel on the floor. It hurts tremendously. Two months ago, I learned from another ortho doc that I was contraindicated Synvisc for it because I have a serious allergy to egg. In fact, I was told that my reaction sounded like a pseudo-septic reaction. I had been getting regular Euflexxa injections for years with no complications or pain so what I went through and am still experiencing was a serious surprise and I think it was treated lightly by my doctor. First the mistake. Then brushing this off. Not good.
I have received injections of Synvisv One in both knees 5 times and have been able to tolerate a lot of activities on both knees. The Mayo Clinic performed the injections using ultrasound as a guide for the needle. I am convinced that without ultrasound many injections miss the exact spot for a correct injection. I have repeated the injections every 6 months for two and half years with great results. My recommendations are to use the Mayo Clinic and ultrasound method of injections. Additionally, I was diagnosed with moderate to severe osteoarthritis two and half years ago and told to schedule knee replacement surgery for both knees.
I got this injection about 6 months after ACL surgery. The injection itself is very uncomfortable. I passed out and vomited following the injection. I’m a collegiate track and cross country athlete so I’m no weanie but this does hurt. I couldn’t run for 2 days after the shot and was back to training by the third. It felt weird but did help with the pain. The effects lasted for about another 4-6 months before my pain and swelling started up again.
I had Synvisc One injections in both knees on the same day. I followed Doc's directions and took it easy for a while post injection. Then worked back into a fairly active routine of weight lifting, hiking, and cycling. After a short but strenous ride both knees completely exploded. Over the course of the weekend, the swelling increased to the point that all I could do was lie on the floor with heels against the wall and constantly ice. I went to the doc when the doors opened on Monday, and they performed joint aspiration (several big tubes), and then shot me up with cortisone injections. Never again!
The first week of getting this injection was hard, but as the weeks went by, the pain in my knee was slowly going away. It has been one month since getting the injection and my knee pain has diminished almost 90%.
I am 76 years young. I got my TKR on left knee in 2012. I started my marathon run 3 years back. My right knee started giving pain about an year back. I had taken the injection 2 days back. It was very smooth, walked without any problem. Put ice bags. So far so good. I will update my status after one month.
I had the injection less than 3 weeks ago. The injection did not feel good. It hurt even though I was numbed. The pressure hurt. I had to limp to my car. Terrible. BUT after about 2 hours I was ways better and within a week I was walking like I did years ago. I am so much better now! Glad I got it. I will get it again if needed however Ill bring a cane or something with me.
Received one shot of Synvisc-one in both knees. The treatment worked well, no issues. My knees felt better. The treatment wore off about 6 months later, so went in for another treatment about 7 months after the first. Had the treatment in both knees. 2 days later my knees started swelling, and 4 days later my knees were locked into place, could not bend at all. My orthopedic surgeon said i had a pseudo-sepsis reaction, which oddly occurs in people with the second or more treatment, not with the first. This is not an allergic reaction. I was treated for this pseudo septic reaction and recovered fully after about two weeks. I’m a healthy active female in my early 50’s, so this reaction could occur to anyone. It is not known who or why various people have this reaction, but when it happens, it is scary.
I suffered a rare side effect to this drug and I will never use it again. I went from painful knees to horrific pain from my hip to ankle in both legs. I lost my ability to walk and had chills, fever, headaches and nothing would help. The doctor prescribed a prednisone pack and it is helping but I still have a long way to go and not sure I will ever be the same. Almost 3 weeks later and I still have to use a walker and still taking prednisone. My energy level is as low as it can get and my immune system keeps trying to rid my body of synvisc. If I could only go back. Be very careful taking these injections and stop immediately if something doesnâ??t feel right at any time in the process.
At 56 years old I run 8 mikes every day and 26 on Saturday. My knees hurt and I thought I would never run again. Three runners on my team had this injection and said it works. I had it 8 years ago. Immediate relief and still today I run pain free.
I had the 2nd of 3 injections in my knee the Monday before Thanksgiving 2019 and by Thanksgiving I could no longer walk. As of 1/18/2020 I still can't walk!! This Drug should be off the market before it hurts someone else!! There are other injections that work that don't have issues like this one does!!
Had my first synviscone shot over two years ago and lost about 15 pounds over a year ago. Feel like my knee is brand new. I was in extreme pain 24/7 and my ortho recommended we try this before knee replacement. It’s been a total game changer for me! I recommend having an ortho do the shot to avoid potential issues with improper injection placement. It was less painful than a cortisone shot. It took about 2 months to feel the full relief, but my goodness, what a difference. It’s worth a try! I’ll keep doing them as long as I can to avoid knee replacement.
Have been suffering 5+ yrs with both knees, medial (inside) meniscus tears frm osteoarthritis. Am 49 yo white female active overweight 5’2” 210lb suburban housewife. These injections hurt on first wk but didn’t feel lik anything wks 2 & 3. Aftr 6wks knee pain completely gone! Was forgetting even had knee injuries and was taking stairs normally first time in yrs! Unfortunately effects have worn off 60-70% by 4mos. Am looking fwd to going for 2nd round at 6mo mark nxt mo. My mother-in-law has had no pain since these injections in 3or4 yrs amazingly. Have Aunt who had similar results to me. She had recommended SynVisc to me stating that it is “wonderful!” No side effects. Definitely recommend trying.
Have severe knee pain, this did not work at all
Beware, I'm on Medicare and still had to pay $560. of the $3000.00 bill. 8 Weeks not even 1% of relief. VERY disappointed, BIG waste of $$ The Doctor told me I would benefit from this medication. She was WRONG and wasted my $$.
Wife, 74, has Bilateral primary osteoarthritis of knees She has been on Euflexxa, three shots over three weeks, every six months, for the past few years with excellent results. We switched insurance and the new insurance insisted on Synvisc or Synvisc One. She went into Cleveland Clinic this morning to get her Synvisc One injection. The Physicians Assistant (PA) had a trainee with her and explained that you have to feel for the soft spot adjacent to the knee cap to determine where to inject. My wife felt more pressure than she had experienced with the Euflexxa, and a little soreness, but almost no pain. She felt better after the injection and was able to walk out of the hospital and return home no more than the normal discomfort. She is currently icing her knees and, so far, is very pleased! I know it is early, but it went really well and gives us hope that the osteoarthritis in her knees won't get progressively worse. Her diagnosis: ====== Right knee: Moderate narrowing of the medial (inside) and lateral (outside) compartment with small osteophytes (bone growths due to loss of cartilage). There is mild to moderate narrowing of the patellofemoral (under the kneecap) compartment. (caused by loss of cartilage) Demineralization (loss of bone) consistent with osteopenia or osteoporosis. ===== Left knee: Mild medial (inside) and severe lateral (outside) compartment narrowing with small osteophytes. (bone growths due to loss of cartilage). Mild patellofemoral (under the kneecap) compartment narrowing with osteophytes. (bone growths due to loss of cartilage). Demineralization (loss of bone) consistent with osteopenia or osteoporosis.
I am a 53 yr. old female and have been a 5-6 day a week runner/hiker since the 1970s. I had the Synvisc injection due to pain from left knee OA. The injection was not painful and I left the doctors office without any problem. That evening and every day since (for the last 2 weeks) I have had excruciating knee pain that makes it painful to walk or function. I have iced my knee, taken anti inflammatory meds and narcotics, and elevated my left knee and rested with no improvement. Synvisc works great for some individuals but it has been a nightmare for me. I would not wish this pain on my worst enemy.

I am 77 years old and have had excellent results with these knee injections. Injections were minimally uncomfortable as the doctor numbed the knee and is always on target. Slightly sore for a couple days then takes about a week for the effects to kick in. For me it is effective for a whole year! I have had the injections Twice and will be making another appointment soon. Very satisfied with the outcome!