How Do IDH1 Inhibitors Work?

Isocitrate dehydrogenase 1 (IDH1) inhibitors are drugs used for treating different types of cancers.

IDH1 is a gene that makes an enzyme isocitrate dehydrogenase 1. This enzyme is mainly found in the fluid-filled space inside the cells called the cytoplasm. IDH1 enzyme is responsible for the production of a molecule called nicotinamide adenine dinucleotide phosphate (NADPH). NADPH is responsible for:

• Breakdown of fats for energy
• Protection of cells from potentially harmful molecules called reactive oxygen species
• Mutation in the IDH1 gene is responsible for increased activity of the IDH1 enzyme. This overactivity causes cell growth to become uncontrolled, leading to the development of cancers.

IDH1 inhibitors are used in the treatment of:

• Acute myeloid leukemia (cancer originating in the bone marrow)
• Cholangiocarcinoma (cancer formed in the bile ducts)

The side effects of IDH1 inhibitors may include:

• Fatigue
• Decreased hemoglobin level
• Decreased white blood cell count
• Increased cholesterol
• Nausea
• Decreased electrolytes
• Vomiting
• Constipation
• Cough
• Headache
• Anemia
• Decreased weight
• Shortness of breath
• Abdominal pain
• Rash
• Muscle pain
• Fever
• Dizziness
• Chest pain
• Low blood pressure

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of IDH1 inhibitors include:

• Ivosidenib
• Tibsovo