How Do IDH2 Inhibitors Work?

Isocitrate dehydrogenase 2 (IDH2) inhibitors are drugs used for treating some cancers.

IDH2 is a gene that makes an enzyme isocitrate dehydrogenase 2. This enzyme is mainly found in the mitochondria, which are the energy-producing centers of the cells. IDH2 enzyme is responsible for the production of a molecule called nicotinamide adenine dinucleotide phosphate (NADPH). NADPH is responsible for:

• Breakdown of fats for energy
• Protection of cells from potentially harmful molecules called reactive oxygen species

Mutation in the IDH2 gene is responsible for altering the function of the IDH2 enzyme. This results in the overproduction of metabolites and compounds that contributes to uncontrollable cell growth, leading to the development of tumors.

IDH2 inhibitors disrupt the overproduction of metabolites and compounds, thus preventing tumor and cancer cell formation.

IDH2 inhibitors are used for treating relapsed/refractory acute myeloid leukemia cancer (a type of cancer of the blood and bone marrow with excess immature white blood cells).

The side effects of IDH2 inhibitors may include:

• Nausea
• Increased total bilirubin 
• Diarrhea
• Vomiting
• Impaired sense of hearing

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of IDH2 inhibitors include:

• Enasidenib
• Idhifa