Inamrinone

Inamrinone is a prescription medication used for the treatment of congestive heart failure.

• Inamrinone is available under the following different brand names: Amrinone

Common side effects of inamrinone include:

• Diarrhea, 
• Fever, 
• Nausea

Serious side effects of inamrinone include:

• Cardiac arrhythmias, 
• Thrombocytopenia, 
• Abnormal results of liver function tests

Rare side effects of inamrinone include:

• None

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Injectable solution

• 5 mg/ml

Congestive heart failure

Adult and geriatric dosage

• Load: 0.75 mg/kg intravenous bolus over 2-3 minutes, then
• 5-10 mcg/kg/min intravenous
• Total daily dose (including loading dose) should not exceed 10 mg/kg/day
• Therapeutic dosage range: 0.5-7 mcg/ml

Pediatric dosage

• Children below 28 days old
• Load as in adults, 0.75 mg/kg intravenous over 3-5 minutes, then
• 3-5 mcg/kg/min intravenous maintenance infusion  
• Bolus dose may need to be repeated after 30 minutes
• Total daily dose should not exceed 10 mg/kg/day
• Therapeutic dosage range: 0.5-7 mcg/ml
• Children above 28 days old
• Load as in adults, 0.75 mg/kg intravenous over 3-5 minutes, then
• 5-15 mcg/kg/min intravenous  
• Not to exceed 10 mg/kg/day
• Therapeutic dosage range: 0.5-7 mcg/ml

Dosage considerations – should be given as follows: 

• See “dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Inamrinone has severe interactions with no other drugs.
• Inamrinone has serious interactions with the following drugs:
  • Ozanimod
  • Ponesimod
• Inamrinone has moderate interactions with the following drugs:
  • Anagrelide
  • Milrinone
• Inamrinone has minor interactions with the following drug:
  • Digoxin

This information does not contain all possible interactions or adverse effects. Visit the RxList drug interaction checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

Contraindications

• Hypersensitivity to inamrinone, milrinone, and bisulfites

Effects of drug abuse

• None

Short-term effects

• See “What Are Side Effects Associated with Using Inamrinone?”

Long-term effects

• See “What Are Side Effects Associated with Using Inamrinone?”

Cautions

• Recent MI
• Electrolyte abnormalities
• Hypotension
• Proarrhythmic effects
• Insufficient cardiac filling pressure
• Severe aortic or pulmonic valvular disease
• Renal impairment
• Concurrent use of disopyramide (may cause hypotension)

Pregnancy and lactation

• Use with caution if the benefits outweigh the risks during pregnancy.
• Lactation
  • Excretion in milk unknown; use with caution