What Is Inclisiran and How Does It Work?
Inclisiran is a prescription medication indicated as an adjunct to diet and exercise to reduce low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia, including heterozygous familial hypercholesterolemia (HeFH).
- Inclisiran is available under the following different brand names: Leqvio
What Are Dosages of Inclisiran?
Adult dosage
Injectable subcutaneous solution
- 284 mg/1.5 mL (prefilled syringe)
Hypercholesterolemia
Adult dosage
- 284 mg subcutaneous into 1 dose initially
- Repeat in 3 months and then every 6 months thereafter
Dosage Considerations – Should be Given as Follows:
- See “Dosages”
What Other Drugs Interact with Inclisiran?
Tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Visit the RxList Drug Interaction Checker for any drug interactions. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.
What Are Warnings and Precautions for Inclisiran?
Contraindications
- Prior serious hypersensitivity reaction to the drug or excipients
Effects of drug abuse
- None
Short-Term Effects
- See “What Are Side Effects Associated with Using Inclisiran?”
Long-Term Effects
- See “What Are Side Effects Associated with Using Inclisiran?”
Cautions
- None
Pregnancy and Lactation
- No data are available on use in pregnant females for drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes
- Discontinue therapy when pregnancy is recognized
- Based on the mechanism of action, therapy may cause fetal harm when administered to pregnant females
- Treatment of hyperlipidemia is not generally necessary during pregnancy; atherosclerosis is a chronic process, and the discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hyperlipidemia for most patients
- Lactation
- There is no information on drug presence in human milk, effects on breastfed infants, or effects on milk production
- Inclisiran was present in the milk of lactating rats in all dosing groups
- When a drug is present in animal milk, it is likely that the drug will be present in human milk
- Oligonucleotide-based products usually have poor bioavailability; consider it unlikely that low levels of inclusion present in milk will adversely impact an infant’s development during lactation
