Methyltestosterone

Methyltestosterone is a prescription medication indicated for replacement therapy in conditions associated with a deficiency or absence of endogenous testosterone such as primary hypogonadism (congenital or acquired) and hypogonadotropic hypogonadism (congenital or acquired) in men and to treat advancing inoperable metastatic (skeletal) mammary cancer in women who are 1-5 years postmenopausal. It is also used to relieve postpartum breast pain and engorgement in women.

• Methyltestosterone is available under the following different brand names: Android, Methitest, Testred

Common side effects of Methyltestosterone include:

nausea

• vomiting
• changes in skin color
• ankle swelling
• frequent erections of the penis and breast enlargement in men
• hoarseness, acne, changes in menstrual periods, or more hair on the face in women

Serious side effects of Methyltestosterone include:

• hives
• difficulty breathing
• swelling of your face, lips, tongue, or throat
• changes in skin color
• increased or ongoing erection of the penis
• shortness of breath (even with mild exertion)
• swelling
• rapid weight gain
• nausea
• upper stomach pain
• itching
• tiredness
• loss of appetite
• dark urine
• clay-colored stools,
• yellowing of the skin or eyes (jaundice)
• development of male characteristics (in women) such as:
• acne
• changes in menstrual periods
• male-pattern hair growth (such as on the chin or chest)
• hoarse or deepened voice
• enlarged clitoris

Rare side effects of Methyltestosterone include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult and pediatric dosage

Tablet: Schedule III

• 10 mg

Capsule: Schedule III

• 10 mg

Androgen Deficiency (Men)

Adult dosage

• Oral: 10-50 mg/day
• Buccal: 5-25 mg/day

Hypogonadism, Climacteric, and Impotence (Men)

Adult dosage

• Oral: 10-40 mg/day

Postpubertal Cryptorchidism (Men)

Adult dosage

• Oral: 30 mg/day

Inoperable Breast Carcinoma (Women)

Adult dosage

• Oral: 50-200 mg/day
• Buccal: 25-100 mg/day

Postpartum Breast pain and Engorgement (Women)

Adult dosage

• Oral: 80 mg/day × 3-5 days post-parturition
• Buccal: 40 mg/day × 3-5 days

To induce pubertal changes in hypogonadal males

Pediatric dosage

• 10 mg orally once a day

Dosage Considerations – Should be Given as Follows:

• See "Dosages"

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, healthcare provider, or pharmacist first.

• Methyltestosterone has severe interactions with no other drugs
• Methyltestosterone has serious interactions with the following drugs:
  • cyclosporine
  • pexidartinib
  • pretomanid
  • warfarin
• Methyltestosterone has moderate interactions with the following drugs:
  • albiglutide
  • epoetin alfa
  • insulin aspart
  • insulin glargine
  • insulin glulisine
  • insulin regular human
  • liraglutide
  • siponimod
  • tacrolimus
  • tolazamide
• Methyltestosterone has minor interactions with at least 26 other drugs

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• Known or suspected prostate cancer, men with breast cancer
• Pregnancy

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Methyltestosterone?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Methyltestosterone?”

Cautions

• Cardiac disease, hepatic disease, renal disease, elderly
• Hypercalcemia may occur in patients with breast cancer
• Risk for jaundice, cholestatic hepatitis, abnormal liver function tests, and potentially fatal hepatic peliosis — discontinue if any of these occur
• Patients are easily sexually aroused

Pregnancy and Lactation

• Do not use during pregnancy
• Lactation
  • Excreted into breast milk; avoid its use