Moexipril

Moexipril is a prescription medication used for the treatment of hypertension (high blood pressure).

• Moexipril is available under the following different brand names: Univasc

Common side effects of Moexipril include:

• dizziness
• lightheadedness
• flushing
• muscle aches
• dry cough, or blurred vision as the body adjusts to the medication
• drowsiness
• headache
• sleep problems (insomnia)
• dry mouth
• sore throat
• vomiting
• diarrhea
• constipation
• skin itching or rash

Serious side effects of Moexipril include:

• hives
• severe stomach pain
• difficulty breathing
• swelling of the face, lips, tongue, or throat
• a light-headed feeling
• sudden weakness or ill feeling, fever, chills, sore throat, painful mouth sores, cough, trouble breathing
• little or no urination
• high potassium--nausea, slow or unusual heart rate, weakness, loss of movement

Rare side effects of Fosaprepitant include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Tablet

• 7.5 mg
• 15 mg

Hypertension

Adult dosage

• Initial: 7.5 mg orally once a day 1 hour before meal or 3.75 mg orally once a day if on thiazide diuretic
• Maintenance: 7.5-30 mg/day orally once a day or divided every 12 hours
• Administer 1 hour before meals

Dosage Considerations – Should be Given as Follows:

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, healthcare provider, or pharmacist first.

• Moexipril has severe interactions with the following drugs:
  • aliskiren
  • protein a column
  • sacubitril/valsartan
• Moexipril has serious interactions with at least 39 other drugs
• Moexipril has moderate interactions with at least 105 other drugs
• Moexipril has minor interactions with at least 29 other drugs

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• Hypersensitivity to moexipril/other angiotensin-converting enzyme (ACE) inhibitors
• History of hereditary or angioedema associated with previous ACE inhibitor treatment
• Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hours of switching to or from sacubitril/valsartan
• Bilateral renal artery stenosis
• Do not coadminister aliskiren in patients with diabetes mellitus (DM) or with renal impairment (ie, glomerular filtration rate less than 60 mL/min/1.73 m2)

Effects of drug abuse

• None

Short-Term Effects

• See "What Are Side Effects Associated with Using Moexipril?"

Long-Term Effects

• See "What Are Side Effects Associated with Using Moexipril?"

Cautions

• Apheresis (low-density lipoprotein) with dextran sulfate, hypertrophic cardiomyopathy, collagen vascular disease, hemodialysis with high flux membrane, and aortic stenosis
• Less effective in African Americans
• Excessive hypotension if concomitant diuretics, hypovolemia, and hyponatremia
• Risk for hyperkalemia, especially with renal impairment, DM, or those taking concomitant K+-elevating drugs
• Dual blockade of the renin-angiotensin system with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risk for hypotension, hyperkalemia, and renal function changes (including acute renal failure) compared with monotherapy
• ACE inhibitors also cause increased bradykinin levels, which putatively mediates angioedema
• Coadministration with mTOR inhibitors (eg, temsirolimus) may increase the risk for angioedema
• Renal impairment may occur
• Neutropenia/agranulocytosis reported
• Cough may occur within the first few months
• Cholestatic jaundice may occur
• Use caution in severe aortic stenosis
• Discontinue immediately if pregnant (see Contraindications and Black Box Warnings)
• Renal impairment

Pregnancy and Lactation

• Use with caution if the benefits outweigh the risks during 1st trimester
• Use in LIFE-THREATENING emergencies when no safer drug is available during 2nd & 3rd trimesters
• Discontinue as soon as pregnancy is detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with a fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
• Lactation
  • Not known if excreted into breast milk; use caution