HOW DO ENDOCRINE MONOCLONAL ANTIBODIES WORK?
Endocrine monoclonal antibodies are drugs used for treating bone disorders.
These antibodies treat hypophosphatemia caused due to excess activity of a phosphaturic hormone fibroblast growth factor-23 (FGF23). FGF23 is a bone-derived hormone that regulates the phosphate level in the body. Phosphate is responsible for vitamin D production in the body. FGF23 signals the kidney to stop reabsorbing phosphate into the bloodstream when it exceeds its level in the body.
Overactivity of FGF23 protein can lead to declined phosphate reabsorption into the bloodstream, leading to low blood phosphate levels (hypophosphatemia).
Endocrine monoclonal antibodies block the overactivity of FGF23, restoring phosphate reabsorption and vitamin D production.
HOW ARE ENDOCRINE MONOCLONAL ANTIBODIES USED?
Endocrine monoclonal antibodies are used for treating:
- X-linked hypophosphatemia (hypophosphatemia caused due to a mutation in the X chromosome)
- Tumor-induced osteomalacia
- Osteoporosis
- Bone loss
WHAT ARE SIDE EFFECTS OF ENDOCRINE MONOCLONAL ANTIBODIES?
Some of the side effects of endocrine monoclonal antibodies include:
- Back pain
- Pain in the legs
- Fatigue
- Nausea
- Shortness of breath
- Diarrhea
- Cough
- Headache
- Vertigo
- Muscle pain
- Upper respiratory tract infection
- Pneumonia
- Bone pain
- Anemia
- Insomnia
- Rash
- Bloating
- Itching
- Irregular heart rate
- Injection site reaction
- Vomiting
- Fever
- Toothache
- Hypersensitivity reaction
- Dizziness
- Constipation
The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.
WHAT ARE NAMES OF ENDOCRINE MONOCLONAL ANTIBODIES?
Generic and brand names of endocrine monoclonal antibodies include:
- Burosumab
- Burosumab-twza
- Crysvita
- Denosumab
- Evenity
- Prolia
- Romosozumab
- Romosozumab-aqqg
- Tepezza
- Teprotumumab
- Teprotumumab-trbw
- Xgeva
