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Multivitamins: Side Effects, Uses, Dosage, Interactions, Warnings

Multivitamins

Reviewed on 10/4/2023

What Are Multivitamins and How Does It Work?

Multivitamins are over-the-counter medications made up of a combination of different vitamins used for treating vitamin deficiency and providing the daily required vitamins. 

  • Multivitamins is available under the following different brand names:  ABDEK [OTC]; Androvite [OTC]; CalciFol; CalciFolic-D; Centamin [OTC]; Centrum Cardio [OTC]; Centrum Flavor Burst [OTC]; Centrum MultiGummies [OTC]; Centrum Performance [OTC]; Centrum Silver Adult 50+ [OTC]; Centrum Silver Ultra Men's [OTC]; Centrum Silver Ultra Women's [OTC]; Centrum Silver [OTC]; Centrum Ultra Men's [OTC]; Centrum Ultra Women's [OTC]; Centrum Women [OTC]; Centrum [OTC]; Corvite 150; CyFolex; DEKAs Bariatric; DEKAs Essential; DEKAs Plus; Diatx Zn; Drinkables Fruits and Vegetables [OTC]; Drinkables MultiVitamins [OTC]; Encora; FeRiva; FeRiva 21/7; FeRivaFA; Ferralet 90; Foltrin; Freedavite [OTC]; Fusion Plus; Fusion [OTC]; Genicin Vita-Q; Geri-Freeda [OTC]; Geriation [OTC]; Geritol Complete [OTC]; Geritol Extend [OTC]; Geritol Tonic [OTC]; Glutofac-MX; Gynovite Plus [OTC]; Hemocyte Plus; Hi-Kovite [OTC]; Iberet-500 [OTC] [DSC]; K-Tan Plus; Monocaps [OTC]; Multilex [OTC] [DSC]; Multilex-T&M [OTC]; Myadec [OTC]; NeoMultivite; Nicadan; NicAzel Forte; NuFera; Nutrimin-Plus [OTC]; Ocuvel; Ocuvite Adult 50+ [OTC]; Ocuvite Extra [OTC]; Ocuvite Lutein [OTC]; Ocuvite [OTC]; One A Day Cholesterol Plus [OTC]; One A Day Energy [OTC]; One A Day Essential [OTC]; One A Day Maximum [OTC]; One A Day Men's 50+ Advantage [OTC]; One A Day Men's Health Formula [OTC]; One A Day Teen Advantage for Her [OTC]; One A Day Teen Advantage for Him [OTC]; One A Day Weight Smart Advanced [OTC]; One A Day Women’s Active Mind & Body [OTC]; One A Day Women’s [OTC]; One A Day® Women's 50+ Advantage [OTC]; One-Daily Multi-Vitamin [OTC]; One-Daily Multi-Vitamin/Iron [OTC]; One-Daily/Iron [OTC]; Optivite P.M.T. [OTC]; PreserVision AREDS 2 Formula + Multivitamin [OTC]; PreserVision AREDS [OTC]; PreserVision Lutein [OTC]; Quflora FE; Quintabs [OTC]; Quintabs-M Iron-Free [OTC]; Quintabs-M [OTC]; Replace Without Iron [OTC]; Replace [OTC]; Repliva 21/7; Strovite; Strovite Forte; Strovite Plus [DSC]; Systane ICaps AREDS2; T-Vites [OTC]; Tab-A-Vite; Thera-Tabs; Thera-Tabs M [OTC]; Theramill Forte [OTC]; TL-HEM 150; Ultra Freeda A-Free [OTC]; Ultra Freeda Iron-Free [OTC]; Ultra Freeda With Iron [OTC]; Viactiv Calcium Flavor Glides [OTC]; Viactiv Flavor Glides [OTC]; Viactiv for Teens [OTC]; Viactiv With Calcium [OTC]; Viactiv [OTC]; Virt-FeFA Plus [DSC]; Vitafol; Xtramins [OTC]; Yelets [OTC]

What Are Side Effects Associated with Using Multivitamins?

Common side effects of Multivitamins include:

  • upset stomach;
  • headache; or
  • unusual or unpleasant taste in the mouth.

Serious side effects of Multivitamins include:

  • hives,
  • difficulty breathing,
  • swelling of the face, lips, tongue, or throat,

Rare side effects of Multivitamins include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088

What Are Dosages of Multivitamins?

Adult dosage

Tablet or capsule

  • 10 mg

Dietary supplement

Adult and geriatric dosage

  • Oral: Daily dose of adult preparations varies by product. Generally, 1 tablet or capsule or 5-15 mL of liquid per day. Consult package labeling. Prescription doses may be higher for burn or cystic fibrosis patients

Dosage Considerations – Should be Given as Follows

  • See “Dosages”.

What Other Drugs Interact with Multivitamins?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Multivitamins may have severe interactions with the following drugs:
    • other dairy products,
    • calcium supplements,
    • or antacids that contain calcium
  • Multivitamins may have serious interactions with no other drugs.
  • Multivitamins may have moderate interactions with no other drugs.
  • Multivitamins may have minor interactions with the following drugs:
    • tretinoin or isotretinoin
    • an antacid
    • an antibiotic
    • a diuretic or "water pill”
    • heart or blood pressure medications
    • a sulfa drug; or
    • NSAIDs (nonsteroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Multivitamins?

Contraindications

  • Hypersensitivity to any component of the formulation; pre-existing hypervitaminosis

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Multivitamins?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Multivitamins?”

Cautions

  • Concerns related to adverse effects:
    • Iron toxicity: Severe iron toxicity may occur in overdose, particularly when ingested by children; iron is a leading cause of fatal poisoning in children; store out of children's reach and in child-resistant containers. Adult preparations may contain amounts of iron that should not be used in children.
  • Disease-related concerns:
    • Hepatic impairment: Use with caution in patients with severe hepatic impairment.
    • Renal impairment: Use with caution in patients with severe renal impairment.
  • Dosage form specific issues:
    • Ethanol: Adult preparations may contain amounts of ethanol that should not be used in children.
    • Phenylalanine: Some products may contain phenylalanine.
  • Other warnings/precautions:
    • RDA values: These are not requirements but are recommended daily intakes of certain essential nutrients.
    • Laboratory test interference: Biotin in blood or other samples were taken from patients who are ingesting high levels of biotin from dietary supplements (including multivitamins; prenatal multivitamins; biotin supplements; and dietary supplements for hair, skin, and nail growth) can cause clinically significant incorrect lab test results. Some testing methods use biotin technology (e.g., troponin, hormone tests), using biotin to bind to specific proteins that are measured to detect health conditions. An increase in the number of reported adverse events, including one death, related to biotin interference with lab tests has been reported. If a lab test result does not correspond with a patient's clinical symptoms, biotin interference should be considered a possible source of error (FDA Safety Communication 2017).

Pregnancy and Lactation

  • Consult your doctor before taking multivitamins

Lactation

  • Consult your doctor before taking multivitamins
References
https://www.emedicinehealth.com/drug-multivitamin/article_em.htm

https://www.uptodate.com/contents/multiple-vitamins-drug-information?search=multivitamin%20supplementation&source=search_result&selectedTitle=3~150&usage_type=default&display_rank=3#F234723