Nilutamide

Nilutamide is a prescription medication indicated for use in combination with surgical castration for the treatment of metastatic prostate cancer (stage D2).

• Nilutamide is available under the following different brand names: Nilandron

Common side effects of Nilutamide include:

• hot flashes
• sweating
• dizziness
• loss of sexual interest/ability
• impotence
• vision changes (such as difficulty seeing when moving into the dark or light, changes in color vision)
• stomach pain
• constipation
• nausea
• signs of alcohol intolerance (such as flushing, tiredness)
• dry skin
• increased sensitivity to touch/pain
• loss of body hair
• nausea
• vomiting
• skin rash
• loss of appetite

Serious side effects of Nilutamide include:

• hives
• difficulty breathing
• swelling of your face, lips, tongue, or throat
• chest pain
• wheezing
• dry cough
• fever
• new or worsening shortness of breath
• flu symptoms
• pale skin
• tiredness
• nausea
• vomiting
• loss of appetite
• stomach pain (upper right side)
• dark urine
• yellowing of the skin or eyes (jaundice)

Rare side effects of Nilutamide include:

• none 

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, coordination loss, unsteady, very stiff muscles, high fever, profuse sweating, or tremors
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, light-headedness, or passing out

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Tablet

• 150 mg

Prostate Cancer

Adult dosage

• 300 mg orally once a day for 30 days, then
• 150 mg orally once a day
• Begin treatment on the same day as or the day after surgical castration

Dosage Considerations – Should be Given as Follows:

• See “Dosages”

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, healthcare provider, or pharmacist first.

• Nilutamide has severe interactions with no other drugs
• Nilutamide has serious interactions with the following drugs:
  • dihydroergotamine intranasal
  • erythromycin base
  • erythromycin ethylsuccinate
  • erythromycin lactobionate
  • erythromycin stearate
  • Nilutamide has moderate interactions with the following drugs:
  • artemether/lumefantrine
  • bazedoxifene/conjugated estrogens
  • clopidogrel
  • conjugated estrogens, vaginal
  • flotufolastat F 18
  • gallium Ga 68 PSMA-11
  • mavacamten
  • pazopanib
  • phenytoin
  • siponimod
  • theophylline
• Nilutamide has minor interactions with the following drugs:
  • levoketoconazole
  • maitake
  • paclitaxel
  • paclitaxel protein bound
  • taurine
  • vincristine liposomal

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, health questions, or concerns.

Contraindications

• Hypersensitivity; severe hepatic and/or respiratory impairment

Effects of drug abuse

• None

Short-Term Effects

• See “What Are Side Effects Associated with Using Nilutamide?”

Long-Term Effects

• See “What Are Side Effects Associated with Using Nilutamide?”

Cautions

• Hepatic impairment
• Hepatitis reported
• Delay in vision adaptation to the dark

Pregnancy and Lactation

• Use with caution if benefits outweigh risks during pregnancy
• Lactation
  • Information not available